Two new morphinane alkaloids from Sinomenium acutum
文献类型：期刊论文
| 作者 | Wang, Xiao-Ling4; Liu, Bing-Rui1,4; Wang, Jun-Ru1; Chen, Chien-Kuang2; Qin, Guo-Wei3; Lee, Shoei-Sheng2 |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 13期号:6页码:523-528 |
| 关键词 | Sinomenium acutum 1-hydroxy-10-oxo-sinomenine 4 5-epoxy-14-hydroxy sinomenine N-oxide |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2011.574617 |
| 文献子类 | Article |
| 英文摘要 | Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine (3). Compound 1 was tested for DPPH inhibition and gave IC50 of 27.9M. Compound 2 was tested for neuroprotective effect and showed significant activity against -amyloid25-35-induced oxidative injury (*P0.05) at 10M in PC-12 cells. |
| 资助项目 | Shaanxi Science and Technology Commission[2010JM2014] ; Shaanxi Education Commission[09JS067] ; Shaanxi Education Commission[2010JK407] ; Baoji Technology Department[08SF01-2] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000290986300007 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278654]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Wang, Xiao-Ling |
| 作者单位 | 1.NW Agr & Forest Univ, Coll Sci, Yangling 712100, Peoples R China; 2.Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Baoji Univ Arts & Sci, Key Lab Phytochem Shaanxi Prov, Baoji 721013, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Xiao-Ling,Liu, Bing-Rui,Wang, Jun-Ru,et al. Two new morphinane alkaloids from Sinomenium acutum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(6):523-528. |
| APA | Wang, Xiao-Ling,Liu, Bing-Rui,Wang, Jun-Ru,Chen, Chien-Kuang,Qin, Guo-Wei,&Lee, Shoei-Sheng.(2011).Two new morphinane alkaloids from Sinomenium acutum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(6),523-528. |
| MLA | Wang, Xiao-Ling,et al."Two new morphinane alkaloids from Sinomenium acutum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.6(2011):523-528. |
入库方式： OAI收割
来源：上海药物研究所
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