Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats
文献类型：期刊论文
| 作者 | Zhao, Ting2; Liu, Xishi2; Zhen, Xuechu1; Guo, Sun-Wei2 |
| 刊名 | REPRODUCTIVE SCIENCES
 |
| 出版日期 | 2011-01 |
| 卷号 | 18期号:1页码:28-45 |
| 关键词 | endometriosis histone deacetylase inhibitor hotplate test hyperalgesia L-tetrahydropalmatine rat |
| ISSN号 | 1933-7191 |
| DOI | 10.1177/1933719110381928 |
| 文献子类 | Article |
| 英文摘要 | One primary goal of medical treatment of endometriosis is to alleviate pain and there is a pressing need for new therapeutics for endometriosis with better efficacy and side-effect profiles. Levo-tetrahydropalmatine (l-THP) has been used as a sedative or analgesic for chronic pains in China since 1970s. In this study, we sought to evaluate the efficacy of l-THP, with or without valproic acid (VPA), in a rat model of endometriosis. We surgically induced endometriosis in 55 adult female rats. Two weeks after, all rats were further divided into 5 groups randomly: untreated, low-and high-dose of l-THP, VPA, and l-THP + VPA. Response latency in hotplate test was measured before the surgery, before and after 3-week treatment of respective drugs. All rats were then sacrificed for analysis. The average lesion size and the immunoreactivity to N-methyl-D-asparate receptor 1 (NMDAR1), acid-sensing ion channel 3 (ASIC3), calcitonin gene-related peptide (CGRP), c-Fos, tyrosine kinase receptor A (TrkA), and histone deacetylase 2 (HDAC2) in dorsal root ganglia (DRG), to phorphorylated p65, HDAC2, TrkA, and CGRP in ectopic endometrium and to phorphorylated p65 and CGRP in eutopic endometrium were evaluated. We found that rats receiving l-THP, with or without VPA, had significantly reduced lesion size and exhibited significantly improved response to noxious thermal stimulus. The treatment also significantly lowered immunoreactivity to all mediators involved in central sensitization and to HDAC2 in DRG, to TrkA and CGRP in ectopic endometrium, and to CGRP in eutopic endometrium. In summary, l-THP reduces lesion growth and generalized hyperalgesia. Thus, l-THP may be a promising therapeutics for endometriosis. |
| WOS关键词 | NF-KAPPA-B ; GENE-RELATED PEPTIDE ; CENTRAL SENSITIZATION ; PAIN HYPERSENSITIVITY ; MEDICAL-MANAGEMENT ; INFLAMMATORY PAIN ; CANCER CELLS ; EXPRESSION ; VALPROATE ; THERAPY |
| 资助项目 | National Science Foundation of China[30872759] ; National Science Foundation of China[30825047] ; Shanghai Science and Technology Commission[074119517] ; Shanghai Science and Technology Commission[09PJD015] ; Shanghai Science and Technology Commission[10410700200] ; State Key Laboratory of Medical Neurobiology of Fudan University[09-11] |
| WOS研究方向 | Obstetrics & Gynecology ; Reproductive Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000290163500003 |
| 出版者 | SAGE PUBLICATIONS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278677]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Guo, Sun-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Stake Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Fudan Univ, Shanghai OB GYN Hosp, Shanghai 200011, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Ting,Liu, Xishi,Zhen, Xuechu,et al. Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats[J]. REPRODUCTIVE SCIENCES,2011,18(1):28-45. |
| APA | Zhao, Ting,Liu, Xishi,Zhen, Xuechu,&Guo, Sun-Wei.(2011).Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats.REPRODUCTIVE SCIENCES,18(1),28-45. |
| MLA | Zhao, Ting,et al."Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats".REPRODUCTIVE SCIENCES 18.1(2011):28-45. |
入库方式： OAI收割
来源：上海药物研究所
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