H-1 NMR-based Metabonomic Analysis of Metabolic Changes in Streptozotocin-induced Diabetic Rats
文献类型：期刊论文
| 作者 | Zhao, Liangcai3; Liu, Xia3 ; Xie, Liyun2; Gao, Hongchang2; Lin, Donghai1,3
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| 刊名 | ANALYTICAL SCIENCES
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| 出版日期 | 2010-12 |
| 卷号 | 26期号:12页码:1277-1282 |
| ISSN号 | 0910-6340 |
| DOI | 10.2116/analsci.26.1277 |
| 文献子类 | Article |
| 英文摘要 | Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia, hypoinsulinemia, and ketosis. To access the biochemical process of diabetes, we applied quantitative H-1 NMR-based metabonomics to analyze urine, serum, and liver extracts from streptozotocin-induced diabetic rats. Principle component analysis (PCA) of H-1 NMR spectra disclosed metabolic pattern differences between diabetic and control rats, and identified the related metabolic changes. The PCA scores plot demonstrated that the diabetic group could be distinguished from the control group, indicating that the metabolic characteristics of the two groups were markedly different. Our work reveals the accumulation of triglycerides, fatty acids and acetoacetate in diabetic rats, and may provide an efficient, convenient way for evaluating the pathological state and biochemical process of diabetes mellitus. |
| WOS关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY ; AMINO-ACID-METABOLISM ; BETA-CELL DESTRUCTION ; CARDIAC METABOLISM ; INSULIN-RESISTANCE ; LIVER ; GLUCOSE ; SERUM ; PROFILES ; TISSUES |
| 资助项目 | National Natural Science Foundation of China[20705037] ; National Natural Science Foundation of China[30730026] ; Medicine & Health Foundation of Zhejiang Province[2010QNA016] ; Chinese Academy of Sciences[KSCX2-YW-R-118] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000285742100011 |
| 出版者 | JAPAN SOC ANALYTICAL CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278698]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Gao, Hongchang |
| 作者单位 | 1.Xiamen Univ, Key Lab Chem Biol Fujian Prov, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 2.Wenzhou Med Coll, Sch Pharm, Anal & Testing Ctr, Wenzhou 325035, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Liangcai,Liu, Xia,Xie, Liyun,et al. H-1 NMR-based Metabonomic Analysis of Metabolic Changes in Streptozotocin-induced Diabetic Rats[J]. ANALYTICAL SCIENCES,2010,26(12):1277-1282. |
| APA | Zhao, Liangcai,Liu, Xia,Xie, Liyun,Gao, Hongchang,&Lin, Donghai.(2010).H-1 NMR-based Metabonomic Analysis of Metabolic Changes in Streptozotocin-induced Diabetic Rats.ANALYTICAL SCIENCES,26(12),1277-1282. |
| MLA | Zhao, Liangcai,et al."H-1 NMR-based Metabonomic Analysis of Metabolic Changes in Streptozotocin-induced Diabetic Rats".ANALYTICAL SCIENCES 26.12(2010):1277-1282. |
入库方式： OAI收割
来源：上海药物研究所
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