Decreased RGS9 protein level in the striatum of rodents undergoing MPTP or 6-OHDA neurotoxicity
文献类型：期刊论文
| 作者 | Yin, Lin-Lin1; Cao, Yan2; Xie, Ke-Qiang2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-08-02 |
| 卷号 | 479期号:3页码:231-235 |
| 关键词 | RGS Striatum MPTP 6-OHDA Western blot |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2010.05.068 |
| 文献子类 | Article |
| 英文摘要 | Western blot has been used to study the time-course effect of the two most popular parkinsonian neurotoxins, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, i.p.) and 6-hydroxydopamine (6-OHDA, intra-substantia nigra), on the expression of several regulators of G-protein signaling (RGS2, 4 and 9) in striatum in rodents. During the few days after MPTP challenge, there was a decline (as expected) in tyrosine hydroxylase expression in the mouse striatum that was accompanied by a decline in RGS9 protein: the latter was specific and did not extend to RGS2 or RGS4 which were resistant to the MPTP challenge. Much the same pattern was observed in rats after 6-OHDA challenge, again, specific to RGS9, although the effect takes a few weeks, rather than a few days, to develop. These results may be helpful for the understanding of molecular mechanism underlying Parkinson's disease (PD) and RGS9 might involve in the striatal function associated with PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | HETEROTRIMERIC G-PROTEINS ; SIGNALING RGS ; MESSENGER-RNA ; RAT-BRAIN ; DOPAMINE-RECEPTORS ; EXPRESSION ; REGULATORS ; LESIONS ; 6-HYDROXYDOPAMINE ; DEGENERATION |
| 资助项目 | Ministry of Science and Technology of China[2004CB720305] ; Shanghai Metropolitan Fund for Research and Development[04DZ14005] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000280100600011 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278802]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Yin, Lin-Lin |
| 作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Pharmacol, Key Lab Neurodegenerat Dis,Minist Educ, Beijing 100053, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Lin-Lin,Cao, Yan,Xie, Ke-Qiang. Decreased RGS9 protein level in the striatum of rodents undergoing MPTP or 6-OHDA neurotoxicity[J]. NEUROSCIENCE LETTERS,2010,479(3):231-235. |
| APA | Yin, Lin-Lin,Cao, Yan,&Xie, Ke-Qiang.(2010).Decreased RGS9 protein level in the striatum of rodents undergoing MPTP or 6-OHDA neurotoxicity.NEUROSCIENCE LETTERS,479(3),231-235. |
| MLA | Yin, Lin-Lin,et al."Decreased RGS9 protein level in the striatum of rodents undergoing MPTP or 6-OHDA neurotoxicity".NEUROSCIENCE LETTERS 479.3(2010):231-235. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。