Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower
文献类型：期刊论文
| 作者 | Zhao, Gang1,3; Qin, Guo-Wei2; Gai, Yue1; Guo, Li-He1,3 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2010-07 |
| 卷号 | 58期号:7页码:950-952 |
| ISSN号 | 0009-2363 |
| 关键词 | Carthamus tinctorius tri-p-coumaroylspermidine transporter inhibitor |
| DOI | 10.1248/cpb.58.950 |
| 文献子类 | Article |
| 英文摘要 | We previously reported that safflower (Carthamus tinctorius L.) ethyl acetate extract (HE) possessed an inhibitory action on serotonin (5HT) uptake in Chinese hamster ovary (CHO) cells expressing 5HT transporter (SERT) (S6 cells). Here, HE was adopted to go through an activity-guided isolation, and then an ingredient with potent SERT inhibitory action was obtained, which was elucidated as N-1,N-5-(Z)-N-10-(E)-tri-p-coumaroylspermidine (CX), a new coumaroylspermidine analog, by using spectroscopic methods including extensive 1D- and 2D-NMR analyses. Preliminary pharmacological study demonstrated that CX was a potent SERT inhibitor. |
| WOS关键词 | L. OIL CAKE ; CARTHAMUS-TINCTORIUS ; MONOAMINE TRANSPORTERS ; DOPAMINE TRANSPORTER ; DERIVATIVES ; FLOWERS ; POLLEN ; N-(P-COUMAROYL)SEROTONIN ; SPERMIDINES ; EXTRACT |
| 资助项目 | Shanghai Government[05DZ19339] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| WOS记录号 | WOS:000279213500014 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278850]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Zhao, Gang |
| 作者单位 | 1.Cell Star Biotechnol Co Ltd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Gang,Qin, Guo-Wei,Gai, Yue,et al. Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):950-952. |
| APA | Zhao, Gang,Qin, Guo-Wei,Gai, Yue,&Guo, Li-He.(2010).Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),950-952. |
| MLA | Zhao, Gang,et al."Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):950-952. |
入库方式： OAI收割
来源：上海药物研究所
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