Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723
文献类型：期刊论文
| 作者 | Zhang, Lei; Liu, Hong
|
| 刊名 | EXPERT OPINION ON THERAPEUTIC PATENTS
 |
| 出版日期 | 2010-07 |
| 卷号 | 20期号:7页码:969-973 |
| 关键词 | diabetes mellitus glycogen metabolism glycogen phosphorylase glycogen synthase hepatic glycogen-targeting subunit protein phosphatase 1 |
| ISSN号 | 1354-3776 |
| DOI | 10.1517/13543771003781923 |
| 文献子类 | Article |
| 英文摘要 | Diabetes mellitus is a major challenge for healthcare systems worldwide because it is strongly associated with several major health risk factors. Currently marketed drugs are insufficient to achieve long-term control of blood glucose levels and induce considerable side effects. The development of more effective drugs for metabolic diseases is still of urgent interest. Recently, inhibiting the interaction of hepatic glycogen-targeting subunit (G(L)) of protein phosphatase 1 and glycogen phosphorylase a (GPa) is emerging as a novel mechanism to combat diabetic hyperglycemia by dephosphorylation and activation of glycogen synthase, converting high blood glucose to liver glycogen. Patent WO2009127723 describes a variety of arylsulfonyl-aminomethylphosphonic acids as small molecule inhibitors of G(L)-GPa interaction and their potential use as pharmaceutical compositions to treat type 1 and type 2 diabetes mellitus. Although lacking detailed in vivo biological data, WO2009127723 represents the first evidence for the novel rationale in antidiabetic pursuit, meriting the attention of the antidiabetic community. |
| WOS关键词 | TYPE-2 DIABETES-MELLITUS ; TARGETING SUBUNIT ; METABOLISM ; THERAPY ; INSULIN ; LIVER |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000280144700005 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278856]  |
| 专题 | 药物化学研究室 药理学第二研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Liu, Hong. Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723[J]. EXPERT OPINION ON THERAPEUTIC PATENTS,2010,20(7):969-973. |
| APA | Zhang, Lei,&Liu, Hong.(2010).Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723.EXPERT OPINION ON THERAPEUTIC PATENTS,20(7),969-973. |
| MLA | Zhang, Lei,et al."Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723".EXPERT OPINION ON THERAPEUTIC PATENTS 20.7(2010):969-973. |
入库方式： OAI收割
来源：上海药物研究所
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