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Metabonomic Study of Aristolochic Acid I-induced Acute Renal Toxicity Urine at Female and Male C57BL/6J Mice Based on H-1 NMR
文献类型：期刊论文
| 作者 | Liu Xia1 ; Xiao Ying1; Gao Hong-Chang2; Ren Jin1; Lin Dong-Hai1
|
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2010-05-10 |
| 卷号 | 31期号:5页码:927-932 |
| 关键词 | Aristolochic acid Renal toxicity Metabonomics NMR Toxicity gender difference |
| ISSN号 | 0251-0790 |
| 文献子类 | Article |
| 英文摘要 | The present work illustrates the metabolic changes of aristolochic acid I-induced acute renal toxicity urine at male and female C57BL/6J mice, which would help to understand the mechanism of renal toxicity and the differences in the metabolism at female and male mice after AAI treatment. The results showed that AAI nephrotoxicity mainly resulted from AAI inhibited the tricaboxylic acid cycle and energy metabolism, damaged the ecology of intestinal flora, changed the osmotic pressure inside and outside the kidney cells, depressed creatinine clearance rate and caused the injury of renal tubular and glomerular. Metabolic pattern analysis also showed that male mice were more sensitive to AAI renal toxicity than the female. These results suggested that urine H-1 NMR-based metabonomics probably provides a novel insight into the study of drug toxicity mechanism and the toxicity gender differences. |
| WOS关键词 | SPECTROSCOPY ; NEPHROTOXICITY ; RATS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3912749 |
| WOS记录号 | WOS:000278159700015 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278899]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Gao Hong-Chang |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Safety & Evaluat Res, Shanghai Inst Mat Med, Analyt Chem Lab,State Key Lab New Drug Res, Shanghai 201203, Peoples R China 2.Wenzhou Med Coll, Anal & Testing Ctr, Sch Pharm, Wenzhou 325035, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu Xia,Xiao Ying,Gao Hong-Chang,et al. Metabonomic Study of Aristolochic Acid I-induced Acute Renal Toxicity Urine at Female and Male C57BL/6J Mice Based on H-1 NMR[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2010,31(5):927-932. |
| APA | Liu Xia,Xiao Ying,Gao Hong-Chang,Ren Jin,&Lin Dong-Hai.(2010).Metabonomic Study of Aristolochic Acid I-induced Acute Renal Toxicity Urine at Female and Male C57BL/6J Mice Based on H-1 NMR.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,31(5),927-932. |
| MLA | Liu Xia,et al."Metabonomic Study of Aristolochic Acid I-induced Acute Renal Toxicity Urine at Female and Male C57BL/6J Mice Based on H-1 NMR".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31.5(2010):927-932. |
入库方式： OAI收割
来源：上海药物研究所
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