中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 分析化学研究室
Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability

文献类型：期刊论文

作者Liu, Cunbao2,3; Hong, Jing3,4; Yang, Hailong2,3; Wu, Jing2,3; Ma, Dongying2,3; Li, Dongsheng2; Lin, Donghai4; Lai, Ren1,2
刊名FREE RADICAL BIOLOGY AND MEDICINE
出版日期2010-05-01
卷号48期号:9页码:1173-1181
关键词Radical scavenging peptide Amphibian skin Redox homeostasis Free radicals
ISSN号0891-5849
DOI10.1016/j.freeradbiomed.2010.01.036
文献子类Article
英文摘要The question of how amphibians can protect themselves from reactive oxygen species when exposed to the sun in an oxygen-rich atmosphere is important and interesting, not only from an evolutionary viewpoint, but also as a primer for researchers interested in mammalian skin biology, in which such peptide systems for antioxidant defense are not well studied. The identification of an antioxidant peptide named antioxidin-RL from frog (Odorrana livida) skin in this report supports the idea that a peptide antioxidant system may be a widespread antioxidant strategy among amphibian skins. Its ability to eliminate most of the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical tested within 2 s, which is much faster than the commercial antioxidant factor butylated hydroxytoluene, suggests that it has a potentially large impact on redox homeostasis in amphibian skins. Cys10 is proven to be responsible for its rapid radical scavenging function and tyrosines take part in the binding of antioxidin-RL to radicals according to our nuclear magnetic resonance assay. (C) 2010 Elsevier Inc. All rights reserved.
WOS关键词TOAD BOMBINA-MAXIMA ; ANTIMICROBIAL PEPTIDES ; OXIDATIVE STRESS ; CYCLIC VOLTAMMETRY ; AMPHIBIAN SKIN ; OXYGEN-UPTAKE ; RANA-PIPIENS ; SECRETIONS ; PRECURSOR ; PEPTIDOMICS
资助项目Chinese National Natural Science Foundation[30830021] ; Chinese Academy of Sciences[KSCX2-YW-G-024] ; Ministry of Science[2008AA02Z133] ; Ministry of Science[2010CB529801/05] ; Ministry of Science Yunnan Province[0803461101]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000276593800006
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/278910]  
专题分析化学研究室
通讯作者Lin, Donghai
作者单位1.Nanjing Agr Univ, Life Sci Coll, Minist Agr, Key Lab Microbiol Engn Agr Environm, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Biotoxin Unit, Kunming 650223, Yunnan, Peoples R China;
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Liu, Cunbao,Hong, Jing,Yang, Hailong,et al. Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability[J]. FREE RADICAL BIOLOGY AND MEDICINE,2010,48(9):1173-1181.
APA Liu, Cunbao.,Hong, Jing.,Yang, Hailong.,Wu, Jing.,Ma, Dongying.,...&Lai, Ren.(2010).Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability.FREE RADICAL BIOLOGY AND MEDICINE,48(9),1173-1181.
MLA Liu, Cunbao,et al."Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability".FREE RADICAL BIOLOGY AND MEDICINE 48.9(2010):1173-1181.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。