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Cynomorium songaricum Extracts Functionally Modulate Transporters of gamma-Aminobutyric Acid and Monoamine

文献类型：期刊论文

作者Zhao, Gang1,2; Wang, Jie1; Qin, Guo-Wei3; Guo, Li-He1,2
刊名NEUROCHEMICAL RESEARCH
出版日期2010-04
卷号35期号:4页码:666-676
关键词Cynomorium songaricum Rupr gamma-Aminobutyric acid Dopamine Norepinephrine Serotonin Transporter modulator
ISSN号0364-3190
DOI10.1007/s11064-009-0118-2
文献子类Article
英文摘要Cynomorium songaricum Rupr. (SY) is a central nervous system-oriented herb material that has actions of anti-dementia, anti-epilepsy, and anti-stress. It is unclear whether SY would be biologically active in functionally regulating neurotransmitter transporters. Here, we assessed these potential actions using Chinese hamster ovary cells expressing gamma-aminobutyric acid (GABA) transporter (GAT-1), dopamine transporter (DAT), norepinephrine transporter (NET), or serotonin transporter (SERT) (i.e. G1, D8, N1, or S6 cells, respectively). It was shown that SY extracts, such as SYw, SYa, SYp, SYc, SYe, and SYb (SY water, ethanol, petroleum ether, chloroform, ethyl acetate, and n-butyl alcohol extract, respectively) increased dopamine/norepinephrine (DA/NE) uptake by corresponding D8/N1 cells and decreased gamma-aminobutyric acid/serotoin (GABA/5HT) uptake by corresponding G1/S6 cells; wherein, the potency or efficacy of SYc for up-regulating DA/NE uptake and that of SYb for inhibiting GABA/5HT uptake were relatively stronger. Additionally, GABA/5HT-uptake inhibition by SY extracts were also seen in cortical synaptosomes, and DA/NE-uptake enhancement by SYc was dependent on the activity of DAT and NET. Thus, SY extracts especially SYc and SYb are novel neurotransmitter-transporter modulators functioning as DAT/NET activators and/or GAT-1/SERT inhibitors.
WOS关键词DOPAMINE TRANSPORTER ; SEROTONIN TRANSPORTER ; NORADRENALINE TRANSPORTER ; GABA TRANSPORTER ; CONSTITUENTS ; INHIBITION ; MECHANISMS ; ADDICTION ; STEMS ; L.
资助项目Shanghai Government[05DZ19339] ; Chinese Academy of Science[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000275820500020
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://119.78.100.183/handle/2S10ELR8/278937]  
专题天然药物化学研究室
通讯作者Guo, Li-He
作者单位1.Cell Star Biotechnol Co Ltd, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Gang,Wang, Jie,Qin, Guo-Wei,et al. Cynomorium songaricum Extracts Functionally Modulate Transporters of gamma-Aminobutyric Acid and Monoamine[J]. NEUROCHEMICAL RESEARCH,2010,35(4):666-676.
APA Zhao, Gang,Wang, Jie,Qin, Guo-Wei,&Guo, Li-He.(2010).Cynomorium songaricum Extracts Functionally Modulate Transporters of gamma-Aminobutyric Acid and Monoamine.NEUROCHEMICAL RESEARCH,35(4),666-676.
MLA Zhao, Gang,et al."Cynomorium songaricum Extracts Functionally Modulate Transporters of gamma-Aminobutyric Acid and Monoamine".NEUROCHEMICAL RESEARCH 35.4(2010):666-676.

入库方式： OAI收割

来源：上海药物研究所

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