Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model
文献类型：期刊论文
| 作者 | Huang, Rongqin1; Ke, Weilun1; Liu, Yang1; Wu, Dongdong2; Feng, Linyin2 ; Jiang, Chen1; Pei, Yuanying1
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| 刊名 | JOURNAL OF THE NEUROLOGICAL SCIENCES
 |
| 出版日期 | 2010-03-15 |
| 卷号 | 290期号:1-2页码:123-130 |
| 关键词 | Lactoferrin-modified nanoparticles Brain gene therapy Multiple dosing administration Parkinson's disease Rotenone |
| ISSN号 | 0022-510X |
| DOI | 10.1016/j.jns.2009.09.032 |
| 文献子类 | Article |
| 英文摘要 | Background: Gene therapy is considered one of the most promising approaches to develop an effective treatment for Parkinson's disease (PD). The existence of blood-brain barrier (BBB) significantly limits its development. In this study, lactoferrin (Lf)-modified nanoparticles (NPs) were used as a potential non-viral gene vector due to its brain-targeting and BBB-crossing ability. Methods and results: The neuroprotective effects were examined in a rotenone-induced chronic rat model of PD after treatment with NPs encapsulating human glial cell line-derived neurotrophic factor gene (hGDNF) via a regimen of multiple dosing intravenous administration. The results showed that multiple injections of Lf-modified NPs obtained higher GDNF expression and this gene expression was maintained for a longer time than the one with a single injection. Multiple dosing intravenous administration of Lf-modified NPs could significantly improve locomotor activity, reduce dopaminergic neuronal loss, and enhance monoamine neurotransmitter levels on rotenone-induced PD rats, which indicates its powerful neuroprotective effects. Conclusion: The findings may have implications for long-term non-invasive gene therapy for neurodegenerative diseases in general. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | HEMIPARKINSONIAN RAT MODEL ; NEUROTROPHIC FACTOR ; DISEASE ; DELIVERY ; BRAIN ; GDNF ; NEURODEGENERATION ; NEUROPROTECTION ; PROTECTION ; VECTOR |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000274987200025 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278946]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Jiang, Chen |
| 作者单位 | 1.Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Neuropharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Rongqin,Ke, Weilun,Liu, Yang,et al. Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2010,290(1-2):123-130. |
| APA | Huang, Rongqin.,Ke, Weilun.,Liu, Yang.,Wu, Dongdong.,Feng, Linyin.,...&Pei, Yuanying.(2010).Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model.JOURNAL OF THE NEUROLOGICAL SCIENCES,290(1-2),123-130. |
| MLA | Huang, Rongqin,et al."Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model".JOURNAL OF THE NEUROLOGICAL SCIENCES 290.1-2(2010):123-130. |
入库方式： OAI收割
来源：上海药物研究所
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