Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins
文献类型：期刊论文
| 作者 | Deng, Jing1; Zhang, Shilei2; Ding, Peng1; Jiang, Hualiang1,3 ; Wang, Wei1,2,3; Li, Jian1
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
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| 出版日期 | 2010-03 |
| 卷号 | 352期号:5页码:833-838 |
| 关键词 | asymmetric Friedel-Crafts reaction indoles isatins organocatalysis |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.200900851 |
| 文献子类 | Article |
| 英文摘要 | The first direct enantioselective Friedel-Crafts reaction of indoles with isatins has been developed. The process is catalyzed by simple cupreine under mild reaction conditions and affords synthetically and biologically interesting, chiral 3-indolyl-3-hydroxy-2-oxindoles in good yields (68-97%) and with high enantioselectivities (76-91%). |
| WOS关键词 | CHIRAL BRONSTED ACID ; DIVERSITY-ORIENTED SYNTHESIS ; ASYMMETRIC ALDOL REACTION ; ORGANIC CATALYSIS ; PHOSPHORIC-ACID ; ALPHA,BETA-UNSATURATED KETONES ; OXINDOLE ALKALOIDS ; CONVOLUTAMYDINE-E ; NATURAL-PRODUCTS ; MICHAEL REACTION |
| 资助项目 | National Natural Science Foundation of China[90813005] ; National Natural Science Foundation of China[20902022] ; 863 Hi-Tech Program of China[2006AA020404] ; China 111 Project[807023] ; NSF[CHE-0704015] ; NSF[CHE-0443580] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000276317800004 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278953]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 2.Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Jing,Zhang, Shilei,Ding, Peng,et al. Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins[J]. ADVANCED SYNTHESIS & CATALYSIS,2010,352(5):833-838. |
| APA | Deng, Jing,Zhang, Shilei,Ding, Peng,Jiang, Hualiang,Wang, Wei,&Li, Jian.(2010).Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins.ADVANCED SYNTHESIS & CATALYSIS,352(5),833-838. |
| MLA | Deng, Jing,et al."Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins".ADVANCED SYNTHESIS & CATALYSIS 352.5(2010):833-838. |
入库方式： OAI收割
来源：上海药物研究所
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