Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties
文献类型：期刊论文
| 作者 | Huang, Ke Xin3; Gong, Jing Xu1,2; Xiong, Wei3; Yang, Lei Xiang2; Wang, Feng2; Tao, Qiao Feng2; Wu, Yi Hang2; Li, Xiao Kun3; Stoeckigt, Joachim2; Zhao, Yu2,3 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2009-09 |
| 卷号 | 20期号:9页码:1030-1033 |
| 关键词 | Silybin derivatives Antioxidant Lipid peroxidation DNA cleavage |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2009.05.009 |
| 文献子类 | Article |
| 英文摘要 | Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups (1-12) were designed and synthesized. The antioxidative properties of these compounds were evaluated. The modified silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin, with exception of the trimethoxylated ester (5) and the aliphatic one (9). Compounds 3, 5, 7, 8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner. (C) 2009 Xiao Kun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS关键词 | ANTIOXIDANT ; SILYMARIN ; MECHANISM ; DISEASE |
| 资助项目 | Zhejiang University[00000000] ; Wenzhou Medical College[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000269956500006 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279146]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Li, Xiao Kun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310058, Zhejiang, Peoples R China; 3.Wenzhou Med Coll, Sch Pharm, Key Lab So Zhejiang TCM R&D, Wenzhou 325035, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Huang, Ke Xin,Gong, Jing Xu,Xiong, Wei,et al. Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties[J]. CHINESE CHEMICAL LETTERS,2009,20(9):1030-1033. |
| APA | Huang, Ke Xin.,Gong, Jing Xu.,Xiong, Wei.,Yang, Lei Xiang.,Wang, Feng.,...&Qu, Jia.(2009).Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties.CHINESE CHEMICAL LETTERS,20(9),1030-1033. |
| MLA | Huang, Ke Xin,et al."Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties".CHINESE CHEMICAL LETTERS 20.9(2009):1030-1033. |
入库方式： OAI收割
来源：上海药物研究所
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