Safflower extracts functionally regulate monoamine transporters
文献类型：期刊论文
| 作者 | Zhao, Gang1,3; Zheng, Xiang-Wei3; Gai, Yue3; Chu, Wen-Jing3; Qin, Guo-Wei2; Guo, Li-He1,3 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2009-07-06 |
| 卷号 | 124期号:1页码:116-124 |
| 关键词 | Safflower Dopamine Norepinephrine Serotonin Reuptake modulator Transporter |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2009.04.002 |
| 文献子类 | Article |
| 英文摘要 | Safflower (HH), the dry flower of Carthamus tinctorius L, has long been used to empirically treat neuropsychological disorders such as stroke and major depression in traditional Chinese medicine, and recently been proven effective for regulating levels of dopamine and serotonin in new-born rat brain. The present study assessed whether HH would be bioactive for functionally regulating monoamine transporters using in vitro drug-screening cell lines. Our current results showed that all solvent-extracted HH fractions, in different degrees, markedly increased both dopamine uptake by Chinese hamster ovary (CHO) cells stably expressing dopamine transporter (DAT) and norepinephrine uptake by CHO cells expressing norepinephrine transporter (NET), and also showed that chloroform (HC), ethyl acetate (HE), and n-butyl alcohol extract strikingly depressed serotonin uptake by CHO cells expressing serotonin transporter (SERT); wherein, the potencies of ethanol extract, HC, HE, and aqueous extract to up-regulate dopamine/norepinephrine uptake and potency of HE to inhibit serotonin uptake were relatively stronger. Further investigation revealed that the enhancement of dopamine/norepinephrine uptake by HC and HE was dependent of DAT/NET activity, and the HE-induced inhibition of serotonin uptake was typical of competition. Thus, HH extracts are novel monoamine transporter modulators functioning as DAT/NET activators and/or SERT inhibitors, and would likely improve neuropsychological disorders through regulating monoamine-transporter activity. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | DOPAMINE TRANSPORTER ; CARTHAMUS-TINCTORIUS ; HYDROXYSAFFLOR-YELLOW ; SEROTONIN DERIVATIVES ; LINOLENIC ACID ; RAT-BRAIN ; IN-VITRO ; MICE ; DYSFUNCTION ; BEHAVIOR |
| 资助项目 | Shanghai Government[05DZ19339] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000268201200014 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279186]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Guo, Li-He |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 201203, Peoples R China 3.Cell Star Biotechnol Co Ltd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Gang,Zheng, Xiang-Wei,Gai, Yue,et al. Safflower extracts functionally regulate monoamine transporters[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,124(1):116-124. |
| APA | Zhao, Gang,Zheng, Xiang-Wei,Gai, Yue,Chu, Wen-Jing,Qin, Guo-Wei,&Guo, Li-He.(2009).Safflower extracts functionally regulate monoamine transporters.JOURNAL OF ETHNOPHARMACOLOGY,124(1),116-124. |
| MLA | Zhao, Gang,et al."Safflower extracts functionally regulate monoamine transporters".JOURNAL OF ETHNOPHARMACOLOGY 124.1(2009):116-124. |
入库方式： OAI收割
来源：上海药物研究所
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