In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)
文献类型：期刊论文
| 作者 | Zhao, G.1,2; Zheng, X. -W.2; Qin, G. -W.3; Gai, Y.2; Jiang, Z. -H.2; Guo, L. -H.1,2 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2009-05 |
| 卷号 | 66期号:9页码:1617-1629 |
| 关键词 | Delta(3),2-hydroxybakuchiol scale-up extraction dopamine transporter reuptake inhibitor Parkinson's disease |
| ISSN号 | 1420-682X |
| DOI | 10.1007/s00018-009-9030-9 |
| 文献子类 | Article |
| 英文摘要 | Cocktail recipes containing Psoralea corylifolia seeds (PCS) are used to empirically treat Parkinson disease. A PCS isolate Delta(3),2-hydroxybakuchiol (BU) can inhibit dopamine uptake in dopamine transporter (DAT) transfected Chinese hamster ovary (CHO) cells, and dopamine reuptake blockade may provide an alternative approach for ameliorating parkinsonism. Here, we assessed the potential dopaminergic neuroprotective, and antiparkinsonian-like activity of BU. BU sample size was increased by using a scale-up extraction paradigm. Pharmacologically, BU significantly protected SK-N-SH cells from 1-methyl-4-phenylpyridinium (MPP+) insult, produced striking inhibitory actions on dopamine/norepinephrine uptake and WIN35,428 binding in synaptosomes on in vivo administration, and significantly preventing poor performance on rotarod and dopaminergic loss in substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice. BU acts by protecting dopaminergic neurons from MPP+ injury and preventing against MPTP-induced behavioral and histological lesions in the Parkinson's disease (PD) model, possibly by inhibiting monoamine transporters. These findings suggest that BU could be meaningful in PD treatment. |
| WOS关键词 | FORCED SWIMMING TEST ; PARKINSONS-DISEASE ; NORADRENALINE TRANSPORTER ; REUPTAKE INHIBITION ; TOTAL FUROCOUMARINS ; TETRAZOLIUM SALT ; SUBSTANTIA-NIGRA ; MPTP ; SEEDS ; MICE |
| 资助项目 | Shanghai Government[05DZ19339] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267484700011 |
| 出版者 | SPRINGER BASEL AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279248]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Guo, L. -H. |
| 作者单位 | 1.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Cell Star Biotechnol Co Ltd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, G.,Zheng, X. -W.,Qin, G. -W.,et al. In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2009,66(9):1617-1629. |
| APA | Zhao, G.,Zheng, X. -W.,Qin, G. -W.,Gai, Y.,Jiang, Z. -H.,&Guo, L. -H..(2009).In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.).CELLULAR AND MOLECULAR LIFE SCIENCES,66(9),1617-1629. |
| MLA | Zhao, G.,et al."In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)".CELLULAR AND MOLECULAR LIFE SCIENCES 66.9(2009):1617-1629. |
入库方式： OAI收割
来源：上海药物研究所
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