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Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis

文献类型：期刊论文

作者Gao, Hongchang1,3; Lu, Qiang2; Liu, Xia3; Cong, Hui2; Zhao, Liangcai3; Wang, Huimin2; Lin, Donghai3
刊名CANCER SCIENCE
出版日期2009-04
卷号100期号:4页码:782-785
ISSN号1347-9032
DOI10.1111/j.1349-7006.2009.01086.x
文献子类Article
英文摘要H-1 nuclear magnetic resonance (NMR)-based metabonomics was used to characterize metabolic profiles of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). We found compared to healthy humans, LC and HCC sera had higher levels of acetate, N-acetylglycoproteins, pyruvate, glutamine, alpha-ketoglutarate, glycerol, tyrosine, 1-methylhistidine and phenylalanine, together with lower levels of low-density lipoprotein, isoleucine, valine, acetoacetate, creatine, choline and unsaturated lipids. Scores plot of pattern recognition analysis were capable of distinguishing LC and HCC patients from healthy humans. These results indicate that serum NMR spectra combined with pattern recognition analysis techniques offer an efficient, convenient way of depicting tumor biochemistry, which may be of great benefit to early diagnosis of human malignant diseases using single blood samples. (Cancer Sci 2009; 100: 782-785)
WOS关键词MULTIVARIATE DATA-ANALYSIS ; SPECTROSCOPY ; MOUSE
资助项目China Postdoctoral Science Foundation[20070410188] ; Knowledge Innovation Program of the Chinese Academy of Sciences[SIMM0709QN-07] ; National Natural Science Foundation of China[20705037] ; National Natural Science Foundation of China[30470351]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000265578100031
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/279272]  
专题分析化学研究室
通讯作者Gao, Hongchang
作者单位1.Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China
2.Nantong Univ, Affiliated Hosp, Clin Lab, Nantong 226001, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Chem Lab, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Gao, Hongchang,Lu, Qiang,Liu, Xia,et al. Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis[J]. CANCER SCIENCE,2009,100(4):782-785.
APA Gao, Hongchang.,Lu, Qiang.,Liu, Xia.,Cong, Hui.,Zhao, Liangcai.,...&Lin, Donghai.(2009).Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis.CANCER SCIENCE,100(4),782-785.
MLA Gao, Hongchang,et al."Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis".CANCER SCIENCE 100.4(2009):782-785.

入库方式： OAI收割

来源：上海药物研究所

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