Antioxidant Peptidomics Reveals Novel Skin Antioxidant System
文献类型：期刊论文
| 作者 | Yang, Hailong1,2; Wang, Xu3; Liu, Xiuhong3; Wu, Jing1,2; Liu, Cunbao1,2; Gong, Weiming4; Zhao, Zhiqiang1,4; Hong, Jing1,5; Lin, Donghai5; Wang, Yizheng6 |
| 刊名 | MOLECULAR & CELLULAR PROTEOMICS
 |
| 出版日期 | 2009-03 |
| 卷号 | 8期号:3页码:571-583 |
| ISSN号 | 1535-9476 |
| DOI | 10.1074/mcp.M800297-MCP200 |
| 文献子类 | Article |
| 英文摘要 | It is generally agreed that reactive oxygen species (ROS) contribute to skin aging, skin disorders, and skin diseases. Skin possesses an extremely efficient antioxidant system. This antioxidant activity is conferred by two systems: antioxidant enzymes and small molecules that can scavenge ROS by donating electrons. No gene-encoded secreted ROS scavengers have been reported. Amphibian skin is a multifunctional organ acting in defense, respiration, and water regulation, although it seems susceptible. Amphibian skins are easily harmed by biological or non-biological attacks such as microorganism infection or radiation injury. Among vertebrates, skins of amphibian are exposed to more dangers of radiation injury than others. Radiation toxicity occurs by directly attacking the genetic material and/or by generating ROS. In addition, amphibian skin respiration and inflammatory response also induce ROS generation. It is rational to hypothesize that amphibian skins should have potent free radical scavenging and radioprotective ability for their survival. Rana pleuraden is distributed in Southwest of China; it lives in the subtropical plateau (altitude around 2300 m) where there is strong ultraviolet radiation and long duration of sunshine. By peptidomics and genomics approaches, a large amount of antioxidant peptides belonging to 11 different groups with variable structures were isolated from the skin secretions of R. pleuraden. Their free radical scavenging and anti-inflammatory abilities were studied. All of these peptide share highly homologous preproregions, although mature antioxidant peptides have very divergent primary structures, suggesting the possibility of a common ancestor. Some peptides were also found to have multifunctional properties, such as combined antioxidant, anti-inflammatory, and antimicrobial activities. According to our knowledge, no gene-encoded specific antioxidant peptides have been reported except metallothionein. Our work possibly reveals a new skin antioxidant system. The current work also provides a large amount of peptide candidates with medical-pharmaceutical significance. Molecular & Cellular Proteomics 8:571-583, 2009. |
| WOS关键词 | TOAD BOMBINA-MAXIMA ; ANTIMICROBIAL PEPTIDES ; OXIDATIVE STRESS ; CYCLIC VOLTAMMETRY ; AMPHIBIAN SKIN ; CDNA CLONING ; SECRETIONS ; FROG ; PRECURSOR ; EPIDERMIS |
| 资助项目 | Chinese National Natural Science Foundation[30830021] ; Chinese Academy of Sciences[KSCXZ-YW-R-088] ; Chinese Academy of Sciences[KSCX2-YW-G-024] ; Ministry of Science[2007AA02Z192] ; Ministry of Science[2007AA100602] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000264240000015 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279307]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Wang, Yizheng |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100009, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Biotoxin Units Key Lab Anim Models & Human Dis Me, Kunming 650223, Yunnan, Peoples R China; 3.Nanjing Agr Univ, Life Sci Coll, Nanjing 210095, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 6.Zhejiang Univ, Inst Feed Sci, Hangzhou 310029, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Hailong,Wang, Xu,Liu, Xiuhong,et al. Antioxidant Peptidomics Reveals Novel Skin Antioxidant System[J]. MOLECULAR & CELLULAR PROTEOMICS,2009,8(3):571-583. |
| APA | Yang, Hailong.,Wang, Xu.,Liu, Xiuhong.,Wu, Jing.,Liu, Cunbao.,...&Lai, Ren.(2009).Antioxidant Peptidomics Reveals Novel Skin Antioxidant System.MOLECULAR & CELLULAR PROTEOMICS,8(3),571-583. |
| MLA | Yang, Hailong,et al."Antioxidant Peptidomics Reveals Novel Skin Antioxidant System".MOLECULAR & CELLULAR PROTEOMICS 8.3(2009):571-583. |
入库方式： OAI收割
来源：上海药物研究所
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