Study on Metabonome in Human Serum with Hepatocellular Carcinoma or Liver Cirrhosis
文献类型：期刊论文
| 作者 | Lu Qiang1; Huang Yi-Hong1; Cong Hui1; Liu Xia2 ; Gao Hong-Chang2; Lin Dong-Hai2; Wang Hui-Min1
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| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2009-02 |
| 卷号 | 37期号:2页码:194-198 |
| 关键词 | Hepatocellular carcinoma liver cirrhosis serum metabonome nuclear magnetic resonance spectroscopy pattern recognition |
| ISSN号 | 0253-3820 |
| 文献子类 | Article |
| 英文摘要 | A comparison for the metabonome in serum samples from patients of LC(liver cirrhosis), HCC(hepatocellular carcinoma) and healthy volunteers were studied with the method of NMR(nuclear magnetic resonance spectroscopy). To explore the potential of applying H-1 NMR-based metabonomics to diagnose HCC, PLS-DA (partial least square-discriminant analysis) was employed to perform the pattern recognition analysis of NMR spectra. In comparison with healthy volunteers, the result show that patients of LC and HCC were characterized by depleted levels of lipids (LDL, low-density lipoprotein and VLDL, very low-density lipoprotein), choline, acetoacetate, etc. and by elevated levels of glutamine, pyruvate, phenylalanine, tyrosine, etc.. The results of PLS-DA analysis shows that HCC patients could be discriminated from healthy volunteers and LC patients with diagnositic sensitivity of 92.1% and false positive rate of 5.7% These were better than the results of serum AFP (alpha-fetoprotein) detection. The results also show that H-1 NMR-based metabonomics couple with PLS-DA analysis is useful for clinical diagnosis of HCC, and the method has the superiorities of sensitiveness, accuracy and good reproducibility. |
| WOS关键词 | BLOOD-PLASMA ; SPECTROSCOPY |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3576811 |
| WOS记录号 | WOS:000265169000006 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279326]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Wang Hui-Min |
| 作者单位 | 1.Nantong Univ, Hosp Nantong Univ, Dept Lab Med, Key Sci Jiangsu Lab Diagnost, Nantong 226001, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu Qiang,Huang Yi-Hong,Cong Hui,et al. Study on Metabonome in Human Serum with Hepatocellular Carcinoma or Liver Cirrhosis[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2009,37(2):194-198. |
| APA | Lu Qiang.,Huang Yi-Hong.,Cong Hui.,Liu Xia.,Gao Hong-Chang.,...&Wang Hui-Min.(2009).Study on Metabonome in Human Serum with Hepatocellular Carcinoma or Liver Cirrhosis.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,37(2),194-198. |
| MLA | Lu Qiang,et al."Study on Metabonome in Human Serum with Hepatocellular Carcinoma or Liver Cirrhosis".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 37.2(2009):194-198. |
入库方式： OAI收割
来源：上海药物研究所
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