Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice
文献类型：期刊论文
| 作者 | Xu, Aimin1,5,6; Wang, Hongbing4; Hoo, Ruby L. C.5,6; Sweeney, Gary2; Vanhoutte, Paul. M.1; Wang, Yu1; Wu, Donghai3; Chu, Wenjing4; Qin, Guowei4; Lam, Karen S. L.5,6 |
| 刊名 | ENDOCRINOLOGY
 |
| 出版日期 | 2009-02 |
| 卷号 | 150期号:2页码:625-633 |
| ISSN号 | 0013-7227 |
| DOI | 10.1210/en.2008-0999 |
| 文献子类 | Article |
| 英文摘要 | Adiponectin is an adipocyte-derived insulin-sensitizing hormone with antidiabetic, antiinflammatory, and antiatherosclerotic properties. A decreased serum level of adiponectin in obesity has been identified as an independent risk factor for diabetes and cardiovascular complications, suggesting that pharmacological intervention aimed at elevating adiponectin production might hold promise for the treatment and/or prevention of these diseases. Here we report the identification of two structurally related natural compounds (astragaloside II and isoastragaloside I) from the medicinal herb Radix Astragali that possess such an activity. Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex. These changes were associated with an alleviation of hyperglycemia, glucose intolerance, and insulin resistance. By contrast, the beneficial effects of these two compounds on insulin sensitivity and glucose metabolism were diminished in adiponectin knockout mice. In conclusion, our results suggest that pharmacological elevation of circulating adiponectin alone is sufficient to ameliorate insulin resistance and diabetes and support the use of adiponectin as a biomarker for future drug discovery. The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases. (Endocrinology 150: 625-633, 2009) |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; HIGH-MOLECULAR-WEIGHT ; COMPLEMENT-RELATED PROTEIN ; FATTY-ACID OXIDATION ; FACTOR-KAPPA-B ; GLOBULAR ADIPONECTIN ; LACKING ADIPONECTIN ; ASTRAGALI RADIX ; GAMMA AGONISTS ; ADIPOSE-TISSUE |
| 资助项目 | Council of Hong Kong[00000000] ; National Natural Science Foundation of China[N_HKU727/05] ; National Natural Science Foundation of China[30518004] ; National 973 program of China[2006CB503908] ; University of Hong Kong[00000000] ; U.S. National Institutes of Health[HL-51586] |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000262851200009 |
| 出版者 | ENDOCRINE SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279329]  |
| 专题 | 天然药物化学研究室 药物安全性评价中心 |
| 通讯作者 | Xu, Aimin |
| 作者单位 | 1.Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China; 2.York Univ, Dept Biol, York YO10 5DD, N Yorkshire, England; 3.Chinese Acad Sci, Guangzhou 100085, Guangdong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China; 6.Univ Hong Kong, Res Ctr Heart Brain Hormones & Healthy Aging, Hong Kong, Hong Kong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Aimin,Wang, Hongbing,Hoo, Ruby L. C.,et al. Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice[J]. ENDOCRINOLOGY,2009,150(2):625-633. |
| APA | Xu, Aimin.,Wang, Hongbing.,Hoo, Ruby L. C..,Sweeney, Gary.,Vanhoutte, Paul. M..,...&Lam, Karen S. L..(2009).Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice.ENDOCRINOLOGY,150(2),625-633. |
| MLA | Xu, Aimin,et al."Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice".ENDOCRINOLOGY 150.2(2009):625-633. |
入库方式： OAI收割
来源：上海药物研究所
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