Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H2O2-induced apoptosis in HUVECs
文献类型：期刊论文
| 作者 | Ma, Ya-Qian1,4; Liu, Meng-Han3; Jiang, Kun4; Guo, Lan2; Qu, Shi-Jin4 ; Wan, Yi-Qun1,2; Tan, Chang-Heng4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018-09 |
| 卷号 | 129页码:179-184 |
| 关键词 | Swietenia macrophylla Limonoids Antioxidant Human umbilical vein endothelial cells Apoptosis |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2018.07.001 |
| 文献子类 | Article |
| 英文摘要 | The fruits of Swietenia macrophylla (skyfruits) are commercially used as healthcare products to improve blood circulation. An investigation of active ingredients of skyfruits led to the isolation of four new limonoids, swietemacrolides A-D (1-4), together with ten known limonoids (5-14) and one proto-limonoid (15). Their structures were elucidated on the basis of MS and NMR data analysis. Swietemacrolide C (3) at the concentration of 10 mu M showed significant protective effect on H2O2-induced apoptosis in human umbilical vascular endothelial cells (HUVECs), while swieteliacate D (5) displayed moderate anti-apoptotic activity. |
| WOS关键词 | ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; MAHAGONI JACQ ; SEEDS ; PATHOPHYSIOLOGY ; CONSTITUENTS ; KING |
| 资助项目 | National Natural Science Foundation of China[31660483] ; Research Program of State Key Laboratory of Food Science and Technology of Nanchang University, China[SKLF-KF-201617] ; Research Program of State Key Laboratory of Food Science and Technology of Nanchang University, China[SKLF-ZZB-201718] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000443663800027 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279597]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Wan, Yi-Qun; Tan, Chang-Heng |
| 作者单位 | 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China; 2.Nanchang Univ, Ctr Anal & Testing, 235 East Nanjing Rd, Nanchang 330047, Jiangxi, Peoples R China 3.Nanchang Univ, Clin Med Coll 2, Nanchang 330006, Jiangxi, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ma, Ya-Qian,Liu, Meng-Han,Jiang, Kun,et al. Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H2O2-induced apoptosis in HUVECs[J]. FITOTERAPIA,2018,129:179-184. |
| APA | Ma, Ya-Qian.,Liu, Meng-Han.,Jiang, Kun.,Guo, Lan.,Qu, Shi-Jin.,...&Tan, Chang-Heng.(2018).Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H2O2-induced apoptosis in HUVECs.FITOTERAPIA,129,179-184. |
| MLA | Ma, Ya-Qian,et al."Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H2O2-induced apoptosis in HUVECs".FITOTERAPIA 129(2018):179-184. |
入库方式： OAI收割
来源：上海药物研究所
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