中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
On-resin peptide ligation via C-terminus benzyl ester

文献类型:期刊论文

作者Zhou, Bin2,3; Faridoon1,2; Tian, Xiaobo2; Li, Jian1,2; Guan, Dongliang1,2; Zheng, Xing3; Guo, Yu3; Huang, Wei1,2
刊名CHINESE CHEMICAL LETTERS
出版日期2018-07
卷号29期号:7页码:1123-1126
关键词On-resin peptide ligation Peptide benzyl ester Native chemical ligation Auxiliary-assisted peptide ligation Peptide elongation
ISSN号1001-8417
DOI10.1016/j.cclet.2018.03.021
文献子类Article; Proceedings Paper
英文摘要Here, we report a new approach of on-resin peptide ligation using C-terminal benzyl ester as the stabilized precursor of thioester, which enables both N-terminal elongation and C-terminal peptide ligation on a Rink Amide resin. On-resin native chemical ligation and auxiliary-assisted peptide ligation were successfully achieved. This method is compatible to both protected and unprotected peptide fragments and has potential application in poor water-soluble peptide ligation. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词PROTEIN CHEMICAL-SYNTHESIS ; SOLID-PHASE SYNTHESIS ; HYDRAZIDE LIGATION ; CHEMISTRY ; THIOESTERS ; LINKER ; ASN
资助项目Hunan Provincial Innovation Foundation for Postgraduate (China)[CX2017B546] ; National Natural Science Foundation of China[21572244]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:6275729
WOS记录号WOS:000438004700022
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/279681]  
专题生物技术药物研发中心(筹)
天然药物化学研究室
药物安全性评价中心
通讯作者Faridoon; Guo, Yu; Huang, Wei
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Ctr Excellence Mol Cell Sci, Ctr Biotherapeut Discovery Res,CAS Key Lab Recept, Shanghai 201203, Peoples R China;
3.Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China;
推荐引用方式
GB/T 7714
Zhou, Bin,Faridoon,Tian, Xiaobo,et al. On-resin peptide ligation via C-terminus benzyl ester[J]. CHINESE CHEMICAL LETTERS,2018,29(7):1123-1126.
APA Zhou, Bin.,Faridoon.,Tian, Xiaobo.,Li, Jian.,Guan, Dongliang.,...&Huang, Wei.(2018).On-resin peptide ligation via C-terminus benzyl ester.CHINESE CHEMICAL LETTERS,29(7),1123-1126.
MLA Zhou, Bin,et al."On-resin peptide ligation via C-terminus benzyl ester".CHINESE CHEMICAL LETTERS 29.7(2018):1123-1126.

入库方式: OAI收割

来源:上海药物研究所

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