ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation
文献类型：期刊论文
| 作者 | Lu, Yu-Chen1,4,5; Wang, Yu-Jun1,4,5 ; Lu, Bin1,4,5; Chen, Ming2,3; Zheng, Ping2,3; Liu, Jing-Gen1,4,5
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2018-04-11 |
| 卷号 | 38期号:15页码:3823-3839 |
| 关键词 | anterior cingulate cortex B5-I neurons brain neural circuit dorsal medial striatum itch |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.3466-17.2018 |
| 文献子类 | Article |
| 英文摘要 | Itch is an unpleasant sensation that initiates scratching behavior. The itch-scratch reaction is a complex phenomenon that implicates supraspinal structures required for regulation of sensory, emotional, cognitive, and motivational aspects. However, the central mechanisms underlying the processing of itch and the interplay of the supraspinal regions and spinal cord in regulating itch-scratch processes are poorly understood. Here, we have shown that the neural projections from anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) constitute a critical circuit element for regulating itch-related behaviors in the brains of male C57BL/6J mice. Moreover, we demonstrate that ACC-DMS projections selectively modulate histaminergic, but not nonhistaminergic, itch-related behavior. Furthermore, photoactivation of ACC-DMS projections has also no significant effects on pain behavior induced by thermal, mechanical, and chemical stimuli except for a relief on inflammatory pain evoked by formalin and complete Freund's adjuvant. We further demonstrate that the dorsal spinal cord exerts an inhibitory effect on itch signal from ACC-DMS projections through B5-I neurons, which represent a population of spinal inhibitory interneurons that mediate the inhibition of itch. Therefore, this study presents the first evidence that the ACC-DMS projections modulate histaminergic itch-related behavior and reveals an interplay between the supraspinal and spinal levels in histaminergic itch regulation. |
| WOS关键词 | SPINOTHALAMIC TRACT NEURONS ; POSITRON-EMISSION-TOMOGRAPHY ; ANTERIOR CINGULATE CORTEX ; HUMAN CEREBRAL-CORTEX ; PREFRONTAL CORTEX ; SPINAL-CORD ; BRAIN ACTIVATION ; CAUDATE-NUCLEUS ; HORN NEURONS ; RESPONSES |
| 资助项目 | Ministry of Science and Technology of China[2013CB835100] ; Ministry of Science and Technology of China[2015CB553502] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[8167132] ; National Natural Science Foundation of China[81401107] ; Committee of Science and Technology of Shanghai[13JC140680] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000429649700018 |
| 出版者 | SOC NEUROSCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279807]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Wang, Yu-Jun; Liu, Jing-Gen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Fudan Univ, Inst Brain Sci, Shanghai 200032, Peoples R China 3.Fudan Univ, Sch Basic Med Sci, Collaborat Innovat Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China; 4.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Yu-Chen,Wang, Yu-Jun,Lu, Bin,et al. ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation[J]. JOURNAL OF NEUROSCIENCE,2018,38(15):3823-3839. |
| APA | Lu, Yu-Chen,Wang, Yu-Jun,Lu, Bin,Chen, Ming,Zheng, Ping,&Liu, Jing-Gen.(2018).ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation.JOURNAL OF NEUROSCIENCE,38(15),3823-3839. |
| MLA | Lu, Yu-Chen,et al."ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation".JOURNAL OF NEUROSCIENCE 38.15(2018):3823-3839. |
入库方式： OAI收割
来源：上海药物研究所
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