Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents
文献类型：期刊论文
| 作者 | Su, Liqiang2; Li, Jiahui1; Zhou, Zhen2; Huang, Dongxia2; Zhang, Yuanjin2; Pei, Haixiang2; Guo, Weikai2; Wu, Haigang2; Wang, Xin2 ; Liu, Mingyao2
|
| 刊名 | European journal of medicinal chemistry
 |
| 出版日期 | 2019-01-15 |
| 卷号 | 162页码:203-211 |
| ISSN号 | 1768-3254 |
| DOI | 10.1016/j.ejmech.2018.11.016 |
| 文献子类 | Article |
| 英文摘要 | Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39-0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266597]  |
| 专题 | 新药研究国家重点实验室 药理学第三研究室 |
| 通讯作者 | Yang, Cai-Guang; Chen, Yihua |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China 2.Shanghai Key Laboratory of Regulatory Biology, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China; |
| 推荐引用方式 GB/T 7714 | Su, Liqiang,Li, Jiahui,Zhou, Zhen,et al. Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents[J]. European journal of medicinal chemistry,2019,162:203-211. |
| APA | Su, Liqiang.,Li, Jiahui.,Zhou, Zhen.,Huang, Dongxia.,Zhang, Yuanjin.,...&Chen, Yihua.(2019).Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.European journal of medicinal chemistry,162,203-211. |
| MLA | Su, Liqiang,et al."Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents".European journal of medicinal chemistry 162(2019):203-211. |
入库方式： OAI收割
来源：上海药物研究所
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