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WT inhibit human hepatocellular carcinoma BEL-7402 cells growth by modulating Akt and ERK1/2 phosphorylation

文献类型：期刊论文

作者ZHANG Zhang1; DUAN Chaohui1; DING Kan2; WANG Zhengtao1
刊名China Journal of Chinese Materia Medica
出版日期2009
卷号34期号:24页码:3277-3280
关键词BEL-7402 Akt ERK1/2 wahonitone BEL-7402 Akt ERK1/2
ISSN号1001-5302
其他题名长梗秦艽酮通过调节Akt和ERK1/2通路抑制人肝癌BEL-7402细胞生长
文献子类Article
英文摘要Objective: To investigate effects of Akt and ERK1/2 signaling pathways on waltonitone (WT) induced cell growth inhibition in human hepatocellular carcinoma BEL-7402 ceils.Method: Cell viability of BEL-7402 cells was examined using MTT assay.Phosphorylation of E Akt and RK1/2 were detected by Western blot analysis,while cell cycle distribution of BEL7402 cells was analyzed by flow cytometry.Result: WT could inhibit the BEL-7402 cells growth,induce the S-phase cell cycle arrest,activate Akt and ERK1/2 phosporylation.Moreover,the cell growth inhibition and S-phase cell cycle arrest induction of WT on BEL-7402 cells could be blocked by Akt and ERK1/2 inhibitors.Conclusion: WT induce the cell cycle arrest and inhibit the cell growth on BEL-7402 cells by modulating Akt and ERK1/2 phosphorylation.
资助项目国家重点自然科学基金[00000000]
WOS研究方向General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3855230
源URL[http://119.78.100.183/handle/2S10ELR8/267976]  
专题药理学第三研究室
通讯作者DING Kan
作者单位1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.;
2.Glycobiology and Glycochemistry Laboratory,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 ZHANG Zhang,DUAN Chaohui,DING Kan,et al. WT inhibit human hepatocellular carcinoma BEL-7402 cells growth by modulating Akt and ERK1/2 phosphorylation[J]. China Journal of Chinese Materia Medica,2009,34(24):3277-3280.
APA ZHANG Zhang,DUAN Chaohui,DING Kan,&WANG Zhengtao.(2009).WT inhibit human hepatocellular carcinoma BEL-7402 cells growth by modulating Akt and ERK1/2 phosphorylation.China Journal of Chinese Materia Medica,34(24),3277-3280.
MLA ZHANG Zhang,et al."WT inhibit human hepatocellular carcinoma BEL-7402 cells growth by modulating Akt and ERK1/2 phosphorylation".China Journal of Chinese Materia Medica 34.24(2009):3277-3280.

入库方式： OAI收割

来源：上海药物研究所

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