Experimental study on apoptosis of S180 tumor induced by total hedysari polysaccharide
文献类型：期刊论文
| 作者 | LEI Fengfeng2; ZHAO Jianxiong2; WANG Xuexi2; YAO Baotai2; DING Kan1
|
| 刊名 | Chinese Traditional Patent Medicine
 |
| 出版日期 | 2008 |
| 卷号 | 30期号:7页码:961-964 |
| 关键词 | total hedysari polysaccharide S180 tumor calcium ion free radical mitochondrial membrane potential |
| ISSN号 | 1001-1528 |
| 其他题名 | 红芪总多糖诱导S180瘤细胞凋亡的实验研究 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study effects and mechanisms of total hedysari polysaccharide(THPS)inducing apoptosis of S180 tumor. METHODS: 60 Kunming mice were divided into 5 groups randomly after inoculating S180 tumor.Sample group(S) and cyclophosphamide group(CY) were injected intraperitoneally with normal sodium and cyclophosphamide respectively.Low dose THPS group(H100),moderate dose THPS group(H200),and high dose THPS group(H400) were injected intraperitoneally with low,moderate,and high dose THPS respectively.The mice were killed after being treated for 14 days.Appearance of tumor was observed by electron microscope,and DNA,RNA,intracellular (Ca~(2+)),free radicals,mitochondrial membrane potential of tumor were determined by laser scanning confocal microscope. RESULTS: Moderate dose THPS raised intracellular Ca~(2+),free radicals and reduced mitochondrial membrane potential and DNA,RNA of tumor. CONCLUSION: Moderate dose THPS induces apoptosis of S180 tumor through raising intracellular Ca~(2+),free radicals and reducing mitochondrial membrane potential. |
| 资助项目 | 甘肃省科技攻关项目(2GS064-A43-020-32)[00000000] ; 兰州大学医学科研基金(LZUYX200601)[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3329264 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268068]  |
| 专题 | 药理学第三研究室 |
| 作者单位 | 1.Shanghai Institute of Material Medica; 2.Institute of Integrated Traditional Chinese Medicine and Western Medicine; 3.Lanzhou, Gansu 730000, China.; 4.Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,et al. Experimental study on apoptosis of S180 tumor induced by total hedysari polysaccharide[J]. Chinese Traditional Patent Medicine,2008,30(7):961-964. |
| APA | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,YAO Baotai,&DING Kan.(2008).Experimental study on apoptosis of S180 tumor induced by total hedysari polysaccharide.Chinese Traditional Patent Medicine,30(7),961-964. |
| MLA | LEI Fengfeng,et al."Experimental study on apoptosis of S180 tumor induced by total hedysari polysaccharide".Chinese Traditional Patent Medicine 30.7(2008):961-964. |
入库方式： OAI收割
来源：上海药物研究所
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