An Experimental Observation of Pulmonary Fibrosis in Rats and Its Transforming Growth Factor beta1 Treated by Total Hedysarum Polybotyssaccharide
文献类型：期刊论文
| 作者 | LEI Fengfeng1; ZHAO Jianxiong1; WANG Xuexi1; YAO Baotai1; DING Kan2
|
| 刊名 | Journal of Chinese Medicinal Materials
 |
| 出版日期 | 2008 |
| 卷号 | 31期号:6页码:873-877 |
| 关键词 | Pulmonary fibrosis Prednisone Total hedysarum polybotyssaccharide TGF-beta1 |
| ISSN号 | 1001-4454 |
| 其他题名 | 红芪总多糖对大鼠肺纤维化及其转化生长因子beta1干预的实验观察 |
| 文献子类 | Article |
| 英文摘要 | Objective: To treat pulmonary fibrosis and study its mechanisms.Methods: Choosing randomly 24 Wistar rats with normal sodium intratracheal injection as normal control group,the rests with heomycin A5 induced fibrosis were divided randomly into model group 24 as positive control,prednisone group 24,total hedysarum polybotyssaccharide(THPS) group 24,THPS and small dose prednisone group 24,and treated with different drugs.6 rats of every group were put to death and observed pathological section,using imaging processing computer to quantitative analysis histomorphology,collagen,and transforming growth beta1(TGF-beta1) on 7,14,30,60 days.Results: The group treated by THPS combination small dose prednisone showed up the most effects in the 3 treatment groups.Conclusion: THPS combination small dose prednisone to treat pulmonary fibrosis of rats is better than classic ways and its efficacy of inhibition TGF-beta1 may be a mechanism. |
| 资助项目 | 甘肃省科技攻关项目(2GS064-A43-020-32)[00000000] ; 兰州大学医学科研基金(LZUYX200601)[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3334206 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268073]  |
| 专题 | 药理学第三研究室 |
| 作者单位 | 1.Institute of the Combination of Traditional Chinese and Western Medicine in Lanzhou University, Lanzhou, Gansu 730000, China.; 2.Shanghai Institute Material Medicine; 3.Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,et al. An Experimental Observation of Pulmonary Fibrosis in Rats and Its Transforming Growth Factor beta1 Treated by Total Hedysarum Polybotyssaccharide[J]. Journal of Chinese Medicinal Materials,2008,31(6):873-877. |
| APA | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,YAO Baotai,&DING Kan.(2008).An Experimental Observation of Pulmonary Fibrosis in Rats and Its Transforming Growth Factor beta1 Treated by Total Hedysarum Polybotyssaccharide.Journal of Chinese Medicinal Materials,31(6),873-877. |
| MLA | LEI Fengfeng,et al."An Experimental Observation of Pulmonary Fibrosis in Rats and Its Transforming Growth Factor beta1 Treated by Total Hedysarum Polybotyssaccharide".Journal of Chinese Medicinal Materials 31.6(2008):873-877. |
入库方式： OAI收割
来源：上海药物研究所
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