中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药理学第三研究室
Synthesis and central none-opioid analgesic activity of SIPI5047

文献类型：期刊论文

作者LI Jianqi2; HUANG Liying2; CHEN Xinjian1; WENG Zhijie2; ZHANG Chunnian2
刊名Acta Pharmaceutica Sinica
出版日期2008
卷号43期号:6页码:611-618
关键词SIPI5047 SIPI5047 synthesis central none-opioid analgesic agent
ISSN号0513-4870
其他题名SIPI5047的合成及非阿片类中枢镇痛活性研究
文献子类Article
英文摘要Compound SIPI5047 was synthesize by using piperazine as starting material in five reaction steps, and its central none-opioid analgesic activity was studied. Its analgesic activity, pharmacological mechanism, action type and drug dependence were well studied in vivo and in vitro. The results show that SIPI5047 has potent analgesic activities in vivo, which is quite similar to morphine and also much more powerful than paraeetamol. SIPI5047 has no efficacy to reduce fever or inflammation, but has an obvious action on central nervous system. SIPI5057 has no apparent affinity with the w-receptor and it is an antagonist that acts on the polyamine site of the NMDA receptor. SIPI5057 appears no drug dependence. SIPI5047 is a novel central none-opioid analgesic agent and more worthy of further research as a new drug candidate.
资助项目国家重点科技攻关计划专题（96-901-01-68）[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3295592
源URL[http://119.78.100.183/handle/2S10ELR8/268093]  
专题药理学第三研究室
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.;
推荐引用方式
GB/T 7714		 LI Jianqi,HUANG Liying,CHEN Xinjian,et al. Synthesis and central none-opioid analgesic activity of SIPI5047[J]. Acta Pharmaceutica Sinica,2008,43(6):611-618.
APA LI Jianqi,HUANG Liying,CHEN Xinjian,WENG Zhijie,&ZHANG Chunnian.(2008).Synthesis and central none-opioid analgesic activity of SIPI5047.Acta Pharmaceutica Sinica,43(6),611-618.
MLA LI Jianqi,et al."Synthesis and central none-opioid analgesic activity of SIPI5047".Acta Pharmaceutica Sinica 43.6(2008):611-618.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。