Study on Depressant effects of THPS on S_180 Tumor-bearing-mice and Its Mechanisms
文献类型：期刊论文
| 作者 | LEI Fengfeng1; ZHAO Jianxiong1; WANG Xuexi1; YAO Baotai1; DING Kan2
|
| 刊名 | Journal of Chinese Medicinal Materials
 |
| 出版日期 | 2007 |
| 卷号 | 30期号:12页码:1548-1551 |
| 关键词 | THPS S_180 tumor IL-2,TNF-alpha NF-kappaB |
| ISSN号 | 1001-4454 |
| 其他题名 | 红芪总多糖对小鼠S_180瘤的抑制作用及其机制研究 |
| 文献子类 | Article |
| 英文摘要 | Objective:to study depressant effect of total hedysarum polybotys saccharids(THPS) on S_(180) tumor-bearing-mice and its mechanisms.Methods:THPS was extracted from Radix Xedysari with water and precipitated with ethanol,determining its molecular weight,purity,saccharide and aldonic acid content.90 Kunming mice were divided into 9 groups randomly.One group was the normal group,the others were divided into 8 groups randomly after inculating S_(180) tumors and were treated with THPS and THPS combination cyclophosphamide(CY) in low,moderate and high dose,to put them to death after 14 days.To determine every tumor weight,the rate of depressant tumor,the contents of IL-2 and TNF-alpha with ELISA,and NF-kappaB with immunochemistry.Results:The moderate dose THPS conspicuously possessed a depressant effect on S_(180) tumor and joint action with combination CY and increased the contents of IL-2,TNF-alpha and NFkappaB of mice.Conclusion:THPS of moderate dose possesses a depressant effect on S_(180) tumor through increasing the contents of IL-2,TNF-alpha and NF-kappaB of mice. |
| 资助项目 | 甘肃省科技攻关项目（2GS064-A43-020-32）[00000000] ; 兰州大学医学科研基金（LZUYX200601）[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3112971 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268136]  |
| 专题 | 药理学第三研究室 |
| 作者单位 | 1.Institute of the Combination of Traditional Chinese and Western Medicine in Lanzhou University, Lanzhou, Gansu 730000, China.; 2.Shanghai Institute Material Medi- cine, Chinese Academy of Science, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,et al. Study on Depressant effects of THPS on S_180 Tumor-bearing-mice and Its Mechanisms[J]. Journal of Chinese Medicinal Materials,2007,30(12):1548-1551. |
| APA | LEI Fengfeng,ZHAO Jianxiong,WANG Xuexi,YAO Baotai,&DING Kan.(2007).Study on Depressant effects of THPS on S_180 Tumor-bearing-mice and Its Mechanisms.Journal of Chinese Medicinal Materials,30(12),1548-1551. |
| MLA | LEI Fengfeng,et al."Study on Depressant effects of THPS on S_180 Tumor-bearing-mice and Its Mechanisms".Journal of Chinese Medicinal Materials 30.12(2007):1548-1551. |
入库方式： OAI收割
来源：上海药物研究所
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