Design and synthesis of quinoxaline derivatives and their antitumor activities
文献类型：期刊论文
| 作者 | Zhao Cuihua3; Chen Yi2 ; Ding Jian2; Duan Wenhu2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2005 |
| 卷号 | 40期号:9页码:814-819 |
| 关键词 | quinoxaline derivative synthesis Antitumor activities |
| ISSN号 | 0513-4870 |
| 其他题名 | 喹喔啉衍生物的设计合成及抗肿瘤活性研究 |
| 文献子类 | Article |
| 英文摘要 | Aim To design and synthesize novel quinoxaline derivatives as antitumor agents. Methods Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline （7）, which reacted with different phenolic compounds to afford quinoxaline derivatives. Results The structures of the target molecules were characterized by elemental analysis, ~I~I NMR, MS, and IR. Conclusion At concentration of 1 * 10^-4 mol · L^-1, some of the derivatives showed equal antitumor activities to XK469. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2166582 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268357]  |
| 专题 | 药理学第一研究室 药物化学研究室 |
| 作者单位 | 1.Shanghai 201203, China.; 2.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China. 3.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; |
| 推荐引用方式 GB/T 7714 | Zhao Cuihua,Chen Yi,Ding Jian,et al. Design and synthesis of quinoxaline derivatives and their antitumor activities[J]. Acta Pharmaceutica Sinica,2005,40(9):814-819. |
| APA | Zhao Cuihua,Chen Yi,Ding Jian,&Duan Wenhu.(2005).Design and synthesis of quinoxaline derivatives and their antitumor activities.Acta Pharmaceutica Sinica,40(9),814-819. |
| MLA | Zhao Cuihua,et al."Design and synthesis of quinoxaline derivatives and their antitumor activities".Acta Pharmaceutica Sinica 40.9(2005):814-819. |
入库方式： OAI收割
来源：上海药物研究所
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