Pathologic effects of RNA methylation
文献类型：期刊论文
| 作者 | Wang Pengyu; Yang Caiguang
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:4页码:431-439 |
| 关键词 | RNA modification N~6-methyladenosine pathologic effects methyltransferase demethylase m6A binding protein |
| ISSN号 | 1004-0374 |
| 其他题名 | RNA甲基化修饰与病理效应 |
| 文献子类 | Article |
| 英文摘要 | RNA methylation represents a new layer in epitranscriptomic regulations on gene expression. Over 100 types of chemical modifications have been identified in cellular RNAs, and N~6-methyladenosine (m~6A) is the most abundant internal modification occurred on RNA. The cellular abundance of m~6A depends on the functional interplay among methyltransferase, demethylase, and m~6A binding proteins. It has been established that RNA methylation has broad and important roles in nearly every aspect of the mRNA life cycle, therefore affecting gene expression. Abnormal m~6A levels induced by defects in RNA epitranscriptomic factors may lead to dysfunction of mRNA and cause diseases. In this short review, we mainly focus on several major RNA methylations and the correlation between RNA modifications and pathologic effects. |
| 资助项目 | 国家自然科学基金项目[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6251274 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269170]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Yang Caiguang |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wang Pengyu,Yang Caiguang. Pathologic effects of RNA methylation[J]. Chinese Bulletin of Life Sciences,2018,30(4):431-439. |
| APA | Wang Pengyu,&Yang Caiguang.(2018).Pathologic effects of RNA methylation.Chinese Bulletin of Life Sciences,30(4),431-439. |
| MLA | Wang Pengyu,et al."Pathologic effects of RNA methylation".Chinese Bulletin of Life Sciences 30.4(2018):431-439. |
入库方式： OAI收割
来源：上海药物研究所
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