Lead compound optimization strategy (6) - improving the plasma stability
文献类型：期刊论文
| 作者 | Wu Xiaowei; Wang Jiang ; Liu Hong
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2018 |
| 卷号 | 53期号:2页码:192-201 |
| 关键词 | plasma stability structural modification lead compound bioisosterism |
| ISSN号 | 0513-4870 |
| 其他题名 | 先导化合物结构优化策略(六)改善化合物血浆稳定性 |
| 文献子类 | Review |
| 英文摘要 | Plasma stability plays an important role in the druggability of lead compound. Improving the plasma stability of compounds by structural modification can lead to good pharmacokinetic and pharmacodynamics properties. This review provides a summary of varieties of structure modification strategies for improving plasma stability including bioisosterism,increasing steric hindrance,ring closure,scaffold hopping and etc. |
| 资助项目 | 国家杰出青年科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6161108 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269179]  |
| 专题 | 药物化学研究室 药物安全性评价中心 |
| 通讯作者 | Liu Hong |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wu Xiaowei,Wang Jiang,Liu Hong. Lead compound optimization strategy (6) - improving the plasma stability[J]. Acta Pharmaceutica Sinica,2018,53(2):192-201. |
| APA | Wu Xiaowei,Wang Jiang,&Liu Hong.(2018).Lead compound optimization strategy (6) - improving the plasma stability.Acta Pharmaceutica Sinica,53(2),192-201. |
| MLA | Wu Xiaowei,et al."Lead compound optimization strategy (6) - improving the plasma stability".Acta Pharmaceutica Sinica 53.2(2018):192-201. |
入库方式： OAI收割
来源：上海药物研究所
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