Synthesis and antiproliferative activities of 5H-benzo[b]carbazole-6,11-diones
文献类型：期刊论文
| 作者 | Cao Sufen1; Xie Qin3; Chen Yi2 ; Duan Wenhu1
|
| 刊名 | Journal of China Pharmaceutical University
 |
| 出版日期 | 2017 |
| 卷号 | 48期号:2页码:157-166 |
| 关键词 | 5H-benzo[b]carbazole-6,11-dione synthesis antiproliferative activity |
| ISSN号 | 1000-5048 |
| 其他题名 | 5H-苯并[b]咔唑类化合物的合成与肿瘤细胞增殖抑制活性 |
| 文献子类 | Article |
| 英文摘要 | A series of 5H-benzo[b]carbazole derivatives were synthesized to find new TopII inhibitors.The substitution pattern at C-9 was discussed.All 16 compounds were tested for their antiproliferative activities against 4 tumor cell lines (SMMC-7721,S1,HCT116,and HeLa) by sulforhodamine B assay.Four compounds were found to inhibit the proliferation of all tested cell lines.And compound 10e displayed the best antiproliferative activity against all 4 tested cell lines with IC_(50) values of 5.06,4.50,5.29,and 6.32 mumol/L,respectively. |
| 资助项目 | 中国科学院上海药物研究所自主部署基金资助项目[00000000] ; 中国科学院战略性先导科技专项资助[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5964870 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269207]  |
| 专题 | 药理学第一研究室 药物化学研究室 |
| 通讯作者 | Chen Yi; Duan Wenhu |
| 作者单位 | 1.School of Pharmacy,East China University of Science & Technology, Shanghai 200237, China.; 2.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 3.School of Pharmacy,Nanchang University, Nanchang, Jiangxi 330031, China.; |
| 推荐引用方式 GB/T 7714 | Cao Sufen,Xie Qin,Chen Yi,et al. Synthesis and antiproliferative activities of 5H-benzo[b]carbazole-6,11-diones[J]. Journal of China Pharmaceutical University,2017,48(2):157-166. |
| APA | Cao Sufen,Xie Qin,Chen Yi,&Duan Wenhu.(2017).Synthesis and antiproliferative activities of 5H-benzo[b]carbazole-6,11-diones.Journal of China Pharmaceutical University,48(2),157-166. |
| MLA | Cao Sufen,et al."Synthesis and antiproliferative activities of 5H-benzo[b]carbazole-6,11-diones".Journal of China Pharmaceutical University 48.2(2017):157-166. |
入库方式： OAI收割
来源：上海药物研究所
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