Research progress of antipsychotics
文献类型：期刊论文
| 作者 | Yang Feipu; He Yang; Wang Zhen ; Wang Yu; Jiang Xiangrui; Shen Jingshan
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2016 |
| 卷号 | 51期号:12页码:1809-1821 |
| 关键词 | antipsychotics D_2/5-HT_(2A) receptor positive symptom negative symptom cognitive deficit |
| ISSN号 | 0513-4870 |
| 其他题名 | 抗精神分裂症药物研究进展 |
| 文献子类 | Review |
| 英文摘要 | Epidemiology indicates that schizophrenia affects approximately 8 of the worlds population. The atypical (second and third generation) antipsychotics generally endowed with D_2/5-HT_(2A) receptors antagonism properties are commonly used as first-line drugs for the treatment of schizophrenia presently. They have been proven effective in the treatment of positive and negative symptoms of schizophrenia, but they are largely ineffective in the treatment of cognitive deficit. Moreover, the atypical antipsychotics are usually associated with cardiovascular and metabolic side effects such as QT prolongation and weight gain. To develop more potent antipsychotics with fewer side effects, more targets have been identified such as D_3, glutamate, H_3 receptors and PDE10A in recent years. Herein, the research progress of antipsychotics is reviewed. |
| 资助项目 | 上海市科委基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5870100 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269226]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | He Yang |
| 作者单位 | CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yang Feipu,He Yang,Wang Zhen,et al. Research progress of antipsychotics[J]. Acta Pharmaceutica Sinica,2016,51(12):1809-1821. |
| APA | Yang Feipu,He Yang,Wang Zhen,Wang Yu,Jiang Xiangrui,&Shen Jingshan.(2016).Research progress of antipsychotics.Acta Pharmaceutica Sinica,51(12),1809-1821. |
| MLA | Yang Feipu,et al."Research progress of antipsychotics".Acta Pharmaceutica Sinica 51.12(2016):1809-1821. |
入库方式： OAI收割
来源：上海药物研究所
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