Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid
文献类型：期刊论文
| 作者 | Tao Yunliang1; Yang Yushe2 ; Wang Haidong1
|
| 刊名 | Chinese Journal of Synthetic Chemistry
 |
| 出版日期 | 2016 |
| 卷号 | 24期号:1页码:75-78 |
| 关键词 | BAL30072 kojic acid BAL30072 gram-negative bacteria intermediate synthesis process improvement |
| ISSN号 | 1005-1511 |
| 其他题名 | (Z) -2-(2-三苯甲基氨基噻唑-4-基) -2-[1,5-二(二苯甲氧基) -4-吡啶酮-2-基甲氧基亚胺]乙酸的合成工艺改进 |
| 文献子类 | Article |
| 英文摘要 | The key intermediate of BAL30072,(Z) -2-(2-tritylaminothiazol-4-yl) -2-[(1,5-dibenzhydryloxy) -4-pyridon-2-ylmethoxyimino]acetic acid with overall yield of 23%,was synthesized by protection of phenolic hydroxyl group,Michael addition,nucleophilic substitution,Mitsunobu reaction, hydrazinolysis,condensation reaction and so on,using kojic acid as the starting material. The structure was confirmed by ~1H NMR and MS. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5775423 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269243]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.School of Petrochemical Engineering,Changzhou University, Changzhou, 213164.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Tao Yunliang,Yang Yushe,Wang Haidong. Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid[J]. Chinese Journal of Synthetic Chemistry,2016,24(1):75-78. |
| APA | Tao Yunliang,Yang Yushe,&Wang Haidong.(2016).Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid.Chinese Journal of Synthetic Chemistry,24(1),75-78. |
| MLA | Tao Yunliang,et al."Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid".Chinese Journal of Synthetic Chemistry 24.1(2016):75-78. |
入库方式： OAI收割
来源：上海药物研究所
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