Synthesis and Antibacterial Activities of Novel Spiropyrimidinetrione Compounds
文献类型：期刊论文
| 作者 | Zhang Yinyong1; Shi Chenghui2; Zhou Xianli1 |
| 刊名 | Chinese Journal of Synthetic Chemistry
 |
| 出版日期 | 2016 |
| 卷号 | 24期号:8页码:653-662 |
| 关键词 | spiropyrimidinetrione benzoxazolinone benzimidazolone type II topoisomerase inhibitor synthesis antibacterial activity |
| ISSN号 | 1005-1511 |
| 其他题名 | 新型螺嘧啶三酮类化合物的合成及其抗菌活性 |
| 文献子类 | Article |
| 英文摘要 | According to the principle of bioisosteric, an intermediate[2-(2,3,4-trifluoro-5-nitrobenzene)-1,3-dioxolame(4)] was prepared by the reaction of nitration, reduction, oxidation and nucleophilic substitution from 2,3,4-trifluorobenzoic acid. Twelve novel spiropyrimidinetrione compounds containing benzoxazolinone or benzimidazolone(12a~12f, 19a~19f) were synthesized by a seven-step reaction from 4. The structures were characterized by ~1H NMR, ~(13)C NMR and ESI-MS. The antibacterial activities of 12 and 19 against methicillin-resistant Ataphylococcus aureus(A), methicillin-resistant Staphylococcus epidermidis(B), penicillin-resistant Streptococcus pneumonia(C) and Streptococcus pyogenes(D) were investigated by CLSI standard.The results indicated that the antibacterial activities of 12 were better than 19.12a exhibited best activities with MIC of 8~16 mug·mL~(-1). |
| WOS研究方向 | Chemistry (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5775448 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269244]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang Yinyong |
| 作者单位 | 1.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Yinyong,Shi Chenghui,Zhou Xianli. Synthesis and Antibacterial Activities of Novel Spiropyrimidinetrione Compounds[J]. Chinese Journal of Synthetic Chemistry,2016,24(8):653-662. |
| APA | Zhang Yinyong,Shi Chenghui,&Zhou Xianli.(2016).Synthesis and Antibacterial Activities of Novel Spiropyrimidinetrione Compounds.Chinese Journal of Synthetic Chemistry,24(8),653-662. |
| MLA | Zhang Yinyong,et al."Synthesis and Antibacterial Activities of Novel Spiropyrimidinetrione Compounds".Chinese Journal of Synthetic Chemistry 24.8(2016):653-662. |
入库方式： OAI收割
来源：上海药物研究所
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