Selective de-O-acetylation of under ultrasound sonication
文献类型：期刊论文
| 作者 | Sun Bingyang1; Tian Xiaobo2; Huang Wei2; Dong Jinhua1 |
| 刊名 | Journal of Shenyang Pharmaceutical University
 |
| 出版日期 | 2015 |
| 卷号 | 32期号:5页码:353-356 |
| 关键词 | Fmoc-Asn(Ac_3GlcNAc) -OH Fmoc-Asn(Ac_3GlcNAc) -OH selective de-O-acetylation ultrasound sonication RP-HPLC |
| ISSN号 | 1006-2858 |
| 其他题名 | 超声条件下选择性脱除Fmoc-Asn(Ac_3GlcNAc) -OH的O-乙酰基 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the selective de-O-acetylation of N-(9-fluorenylmethoxycarbonyl) -N'- (2-acetylamido-2-deoxy-beta-D-glucopyranosyl) -L-asparagine (Fmoc-Asn (Ac_3GlcNAc) -OH). Methods The Fmoc-Asn(Ac_3GlcNAc) -OH was treated in ultrasound sonication conditions for selective de-O-acetylation. The optimal conditions were obtained through the monitoring of HPLC profiles of reaction. Results Under the condition of alkali reagent, the reaction had many impurities. But under the condition of ultrasonic, the reaction was very pure and had a high rate of production. Conclusions Fmoc-Asn(Ac_3GlcNAc) -OH and Fmoc-Ser(Ac_3GlcNAc) -OH can be selectively de-O-acteylated under ultrasound sonication with more than 90% yield. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5441064 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269280]  |
| 专题 | 生物技术药物研发中心（筹） 药物安全性评价中心 |
| 通讯作者 | Huang Wei |
| 作者单位 | 1.Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Sun Bingyang,Tian Xiaobo,Huang Wei,et al. Selective de-O-acetylation of under ultrasound sonication[J]. Journal of Shenyang Pharmaceutical University,2015,32(5):353-356. |
| APA | Sun Bingyang,Tian Xiaobo,Huang Wei,&Dong Jinhua.(2015).Selective de-O-acetylation of under ultrasound sonication.Journal of Shenyang Pharmaceutical University,32(5),353-356. |
| MLA | Sun Bingyang,et al."Selective de-O-acetylation of under ultrasound sonication".Journal of Shenyang Pharmaceutical University 32.5(2015):353-356. |
入库方式： OAI收割
来源：上海药物研究所
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