Progress in the study of small molecule inhibitors of HSP90
文献类型：期刊论文
| 作者 | Ren Jing2; Yan Bibo1; Shi Feng2; Xiong Bing2 ; Shen Jingkang2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2015 |
| 卷号 | 50期号:6页码:640-649 |
| 关键词 | HSP90 HSP90 client protein tumor inhibitor |
| ISSN号 | 0513-4870 |
| 其他题名 | HSP90小分子抑制剂研究进展 |
| 文献子类 | Review |
| 英文摘要 | HSP90, which is the biomarker of cell stress and endogenous protective protein, functions as a molecular chaperone. Many client proteins of HSP90, including EGFR, Met, Raf-1, IKK and p53, play important roles in the occurrence and development of tumor. Binding of HSP90 inhibitors triggers the deactivation of HSP90, resulting in client protein degradation, and hence inhibits the tumor growth by blocking multiple targets involved in signaling of tumor proliferation. This review summarizes recent development of small molecule inhibitors bound to N-terminal of HSP90. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 国家"新药创制"科技重大专项资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5442916 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269281]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.College of Electronics and Information, Yangtze University, Jingzhou, Hubei 434023, China. 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Ren Jing,Yan Bibo,Shi Feng,et al. Progress in the study of small molecule inhibitors of HSP90[J]. Acta Pharmaceutica Sinica,2015,50(6):640-649. |
| APA | Ren Jing,Yan Bibo,Shi Feng,Xiong Bing,&Shen Jingkang.(2015).Progress in the study of small molecule inhibitors of HSP90.Acta Pharmaceutica Sinica,50(6),640-649. |
| MLA | Ren Jing,et al."Progress in the study of small molecule inhibitors of HSP90".Acta Pharmaceutica Sinica 50.6(2015):640-649. |
入库方式： OAI收割
来源：上海药物研究所
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