Enantioselective synthesis of(+)-laburnine and(-)-isoretronecanol by L-prolinecatalyzed self-aldol reaction
文献类型：期刊论文
| 作者 | Ma Shichao2; Cao Sufeng2; Mei Desheng1; Duan Wenhu2
|
| 刊名 | West China Journal of Pharmaceutical Sciences
 |
| 出版日期 | 2015 |
| 卷号 | 30期号:2页码:167-171 |
| 关键词 | (+) laburnine (-)-isoretronecanol Self-aldol reaction Organocatalysis Proline (+) Laburnine (-)-isoretronecanol Enantioselective synthesis |
| ISSN号 | 1006-0103 |
| 其他题名 | L-脯氨酸催化的(+)-laburnine和(-)-isoretronecanol的不对称合成 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To explore a novel,effective and concise enantioselective approach to the synthesis of(+)-laburnine and(-)-isoretronecanol. METHODS The chiral center was constructed by L-porline promoted self-aldol reaction with known compounds initial materials. A number of transformations including reduction,protection,tosylation,nucleophilic substitution,hydrolysis,mesylation,reuctive cyclization and deprotection were involved in this approach. RESULTS(+)-laburnine and(-)-isoretronecanol were synthesized by eight steps. CONCLUSION The total yield is 27% and 8%,respectively. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5404752 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269286]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Duan Wenhu |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.; |
| 推荐引用方式 GB/T 7714 | Ma Shichao,Cao Sufeng,Mei Desheng,et al. Enantioselective synthesis of(+)-laburnine and(-)-isoretronecanol by L-prolinecatalyzed self-aldol reaction[J]. West China Journal of Pharmaceutical Sciences,2015,30(2):167-171. |
| APA | Ma Shichao,Cao Sufeng,Mei Desheng,&Duan Wenhu.(2015).Enantioselective synthesis of(+)-laburnine and(-)-isoretronecanol by L-prolinecatalyzed self-aldol reaction.West China Journal of Pharmaceutical Sciences,30(2),167-171. |
| MLA | Ma Shichao,et al."Enantioselective synthesis of(+)-laburnine and(-)-isoretronecanol by L-prolinecatalyzed self-aldol reaction".West China Journal of Pharmaceutical Sciences 30.2(2015):167-171. |
入库方式： OAI收割
来源：上海药物研究所
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