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Hypoglycemic activity of polyphenol-rich extract from Cinnamomun japonicum Sieb

文献类型：期刊论文

作者Chen Liang4; Sun Peng4; Wang Ting1; Xu Na2; Jia Qi4; Li Yiming4; Chen Kaixian3
刊名Chinese Traditional Patent Medicine
出版日期2014
卷号36期号:2页码:229-235
关键词Cinnamomun japonicum Sieb. polyphenol pancreatic INS-1 beta cells type 2 diabetic db /db mice anti-diabetic activity
ISSN号1001-1528
其他题名天竺桂多酚提取物降血糖活性研究
文献子类Article
英文摘要AIM To explore the structure and hypoglycemic activity of the polyphenols-rich extract isolated from Cinnamomun japonicum Sieb. METHODS HPLC and ESI-MS methods were employed to characterize their structures. The biological activity of the extract was determined on pancreatic INS-1 beta cells and db /db type 2 diabetic mice model. The effects of the extract on the vitality of INS-1 cell under palmitate or H_2O_2 stimulation were examined. RESULTS The main polyphenols found in C. japonicum extracts were identified as B-type polyphenols, and that the extract could protect INS-1 cells from palmitate or H_2O_2 damage. The reaction oxygen level was also significantly reduced in the extract-treated INS-1 cells under H_2O_2 induction in a dose dependent manner. After the administration of the extract once daily for 4 weeks at the dosage of 200 mg /kg,the fasting blood glucose of db /db mice was reduced,and the oral glucose and insulin tolerances were also improved. CONCLUSION Btype polyphenols from C. japonicum have anti-diabetic activity. It could protect pancreatic beta cells from palmitate or H_2O_2 induced damage via reducing the intracellular reaction oxygen level,which could be one possible reason for the improvement in the symptoms of diabetes in db /db mice.
资助项目国家自然科学基金面上项目[00000000] ; 上海市中药现代化课题[00000000] ; 上海市药剂学重点学科建设项目[00000000] ; 新药研究国家重点实验室开放课题[00000000]
WOS研究方向General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5128457
源URL[http://119.78.100.183/handle/2S10ELR8/269297]  
专题药理学第三研究室
作者单位1.The Third Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai 201203, China.;
2.Department of Endocrinology,Central Hospital of Nanyang, Henan 473009, China.;
3.School of Pharmacy,Shanghai University of Traditional Chinese Medicine, State Key Laboratory of Drug Research, Shanghai 201203, China.
4.School of Pharmacy,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.;
推荐引用方式
GB/T 7714		 Chen Liang,Sun Peng,Wang Ting,et al. Hypoglycemic activity of polyphenol-rich extract from Cinnamomun japonicum Sieb[J]. Chinese Traditional Patent Medicine,2014,36(2):229-235.
APA Chen Liang.,Sun Peng.,Wang Ting.,Xu Na.,Jia Qi.,...&Chen Kaixian.(2014).Hypoglycemic activity of polyphenol-rich extract from Cinnamomun japonicum Sieb.Chinese Traditional Patent Medicine,36(2),229-235.
MLA Chen Liang,et al."Hypoglycemic activity of polyphenol-rich extract from Cinnamomun japonicum Sieb".Chinese Traditional Patent Medicine 36.2(2014):229-235.

入库方式： OAI收割

来源：上海药物研究所

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