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Lead compound optimization strategy (2) structure optimization strategy for reducing toxicity risks in drug design

文献类型：期刊论文

作者Liu Hailong2; Wang Jiang1; Lin Daizong1; Liu Hong2
刊名Acta Pharmaceutica Sinica
出版日期2014
卷号49期号:1页码:1-15
关键词CYP450 drug toxicity alert structure idiosyncratic adverse drug reaction CYP450 optimization strategy
ISSN号0513-4870
其他题名先导化合物结构优化策略(二) 结构修饰降低潜在毒性
文献子类Article
英文摘要Idiosyncratic adverse drug reactions (IDR) induce severe medical complications or even death in patients. Alert structure in drugs can be metabolized as reactive metabolite (RM) in the bodies, which is one of the major factors to induce IDR. Structure modification and avoidance of alert structure in the drug candidates is an efficient method for reducing toxicity risks in drug design. This review briefly summarized the recent development of the methodologies for structure optimization strategy to reduce the toxicity risks of drug candidates. These methods include blocking metabolic site, altering metabolic pathway, reducing activity, bioisosterism, and prodrug.
资助项目国家杰出青年科学基金资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5033879
源URL[http://119.78.100.183/handle/2S10ELR8/269355]  
专题药物化学研究室
通讯作者Liu Hong
作者单位1.Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.School of Pharmacy, China Pharmaceutical University, Key Laboratory of Receptor Research, Chinese Academy of Sciences, Nanjing, Jiangsu 210009, China.;
推荐引用方式
GB/T 7714		 Liu Hailong,Wang Jiang,Lin Daizong,et al. Lead compound optimization strategy (2) structure optimization strategy for reducing toxicity risks in drug design[J]. Acta Pharmaceutica Sinica,2014,49(1):1-15.
APA Liu Hailong,Wang Jiang,Lin Daizong,&Liu Hong.(2014).Lead compound optimization strategy (2) structure optimization strategy for reducing toxicity risks in drug design.Acta Pharmaceutica Sinica,49(1),1-15.
MLA Liu Hailong,et al."Lead compound optimization strategy (2) structure optimization strategy for reducing toxicity risks in drug design".Acta Pharmaceutica Sinica 49.1(2014):1-15.

入库方式： OAI收割

来源：上海药物研究所

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