Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability
文献类型：期刊论文
| 作者 | Wang Jiang ; Liu Hong
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:10页码:1521-1531 |
| 关键词 | metabolism stability lead compound block metabolic site lipophilicity half life |
| ISSN号 | 0513-4870 |
| 其他题名 | 先导化合物结构优化策略(一)改变代谢途径提高代谢稳定性 |
| 文献子类 | Review |
| 英文摘要 | Lead compound optimization plays an important role in new drug discovery and development. The strategies for changing metabolic pathways can modulate pharmacokinetic properties, prolong the half life, improve metabolism stability and bioavailability of lead compounds. The strategies for changing metabolic pathways and improving metabolism stability are reviewed. These methods include blocking metabolic site, reduing lipophilicity, changing ring size, bioisosterism, and prodrug. |
| 资助项目 | 国家杰出青年科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4949724 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269369]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu Hong |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wang Jiang,Liu Hong. Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability[J]. Acta Pharmaceutica Sinica,2013,48(10):1521-1531. |
| APA | Wang Jiang,&Liu Hong.(2013).Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability.Acta Pharmaceutica Sinica,48(10),1521-1531. |
| MLA | Wang Jiang,et al."Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability".Acta Pharmaceutica Sinica 48.10(2013):1521-1531. |
入库方式： OAI收割
来源：上海药物研究所
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