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Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles

文献类型：期刊论文

作者Gao, Mengying1,2; Yang, Yaxi1; Chen, Hua2; Zhou, Bing1
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2018-01-04
卷号360期号:1页码:100-105
关键词Cp*Rh(III) catalyst C-H activation Diazo compounds 2,3-fused indoles
ISSN号1615-4150
DOI10.1002/adsc.201700974
文献子类Article
英文摘要A Rhodium-catalyzed C2-H functionalization of indoles with diazo compounds, followed by intramolecular nucleophilic addition to C=O or C=C bonds, is reported for divergent synthesis of 2,3-fused indoles. Besides acceptor/acceptor diazo compounds, donor/acceptor diazo compounds are broadly tolerated, giving various 2,3-fused indoles with perfect diastereocontrol. Notably, a selective C-H dialkylation reaction at C2 and C7 position of indoles has also been developed by simply changing the reaction conditions. This environmentally benign transformation proceeds under mild conditions and gives dinitrogen as the only by-product.
WOS关键词NONREARRANGED MONOTERPENOID UNIT ; ALPHA-DIAZOCARBONYL COMPOUNDS ; N-TOSYLHYDRAZONES ; BOND ACTIVATION ; CARBENOID FUNCTIONALIZATION ; RH(III)-CATALYZED SYNTHESIS ; CASCADE REACTIONS ; COMPOUNDS ACCESS ; FUSED INDOLES ; ALKYNES
资助项目Youth innovation promotion association[2017333]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000419227800006
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/272292]  
专题药物化学研究室
通讯作者Yang, Yaxi; Chen, Hua; Zhou, Bing
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Zu Chong, Shanghai 201203, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China;
推荐引用方式
GB/T 7714		 Gao, Mengying,Yang, Yaxi,Chen, Hua,et al. Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles[J]. ADVANCED SYNTHESIS & CATALYSIS,2018,360(1):100-105.
APA Gao, Mengying,Yang, Yaxi,Chen, Hua,&Zhou, Bing.(2018).Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles.ADVANCED SYNTHESIS & CATALYSIS,360(1),100-105.
MLA Gao, Mengying,et al."Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles".ADVANCED SYNTHESIS & CATALYSIS 360.1(2018):100-105.

入库方式： OAI收割

来源：上海药物研究所

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