Cross-Dehydrogenative Coupling Reactions Applied in the Construction of Privileged Heterocycles
文献类型：期刊论文
| 作者 | Hu, Wei; Long, Yaqiu |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2017-11-25 |
| 卷号 | 37期号:11页码:2850-2858 |
| 关键词 | cross-dehydrogenative coupling C-H functionalization drug-like privileged scaffold |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc201703033 |
| 文献子类 | Review |
| 英文摘要 | The reactions in which a new C-C bond is formed via a direct coupling of two C-H bonds are termed as cross dehydrogenative coupling (CDC). The coupling reactions would not need the pre-activation of the inert C-H bonds by any functional groups, featured with straightforwardness, atom- and step-economy and environmently benigness. Heterocycles are widely found in bioactive natural products and pharmaceuticals, designated as drug-like privileged scaffolds since they endowed diverse pharmacological effects. Preparation of these privileged structures by means of CDC confers distinctive advantages and enhances the discovery of lead compounds in medicinal chemistry. The application of CDC reactions in the synthesis of the heterocycles of pharmaceutical interest in recent years is summarized, focused on the construction of privileged scaffolds, such as indole, pyrrole, quinazoline, quinoxaline and the middle size and poly ring systems. |
| WOS关键词 | C-H FUNCTIONALIZATION ; ONE-POT SYNTHESIS ; EFFICIENT SYNTHESIS ; ALLYLIC ALKYLATION ; BOND-FORMATION ; INDOLES ; CYCLIZATION ; INHIBITORS ; HYDRAZONES ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[81325020] ; National Natural Science Foundation of China[81761128022] |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6122664 |
| WOS记录号 | WOS:000424747300005 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272394]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Long, Yaqiu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Wei,Long, Yaqiu. Cross-Dehydrogenative Coupling Reactions Applied in the Construction of Privileged Heterocycles[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2017,37(11):2850-2858. |
| APA | Hu, Wei,&Long, Yaqiu.(2017).Cross-Dehydrogenative Coupling Reactions Applied in the Construction of Privileged Heterocycles.CHINESE JOURNAL OF ORGANIC CHEMISTRY,37(11),2850-2858. |
| MLA | Hu, Wei,et al."Cross-Dehydrogenative Coupling Reactions Applied in the Construction of Privileged Heterocycles".CHINESE JOURNAL OF ORGANIC CHEMISTRY 37.11(2017):2850-2858. |
入库方式： OAI收割
来源：上海药物研究所
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