Structure analysis of a novel heteroxylan from the stem of Dendrobium officinale and anti-angiogenesis activities of its sulfated derivative
文献类型：期刊论文
| 作者 | Yue, Han1,2,3; Liu, Yanqiu2,3,4; Qu, Huanhuan2,3,5; Ding, Kan1,2,3,5
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2017-10 |
| 卷号 | 103页码:533-542 |
| 关键词 | Dendrobium officinale Polysaccharide Anti-angiogenesis Heteroxylan Sulfated derivative |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2017.05.097 |
| 文献子类 | Article |
| 英文摘要 | Dendrobium officinale Kimura et Migo (Tie-Pi-Shi-Hu), a precious folk medicine exhibiting multiple bioactivities, including antitumor, immune-enhancing and so on. Although evidences showed polysaccharide is one of the major bioactive substances from this herb, several of them were homogenous with fine structures elucidated. In this study, we showed a novel homogeneous heteroxylan obtained from alkali extracted crude polysaccharide. It composed of arabinose, xylose, glucose and 4-O-methylglucuronic acid (4-MGA) as well as trace amount of rhamnose and galactose in a ratio of 8.9:62.7:8.5:12.3:3.9:3.7. We further showed that it contained a backbone of 1,4-linked beta-D-xylan, with branches of 1,4-linked alpha-D-glucose, 1,3-linked alpha-L-rhamnose, and terminal-linked alpha-L-arabinose, beta-D-galactose, 4-MGA, and beta-D-xylose directly or indirectly attached to C-2 position of glycosyl residues on backbone. The sulfated derivative with substitution degree about 0.9 was prepared according to the chlorosulfonic acid (CSA)-pyridine method. Bioactivity tests suggested that the sulfated polysaccharide could significantly disrupt tube formation and inhibit the migration of human microvascular endothelial cells (HMEC-1) at a low concentration (0.29 mu M) in a dose-dependent way without significant cytotoxity. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | XYLAN DERIVATIVES ; POLYSACCHARIDE ; (4-O-METHYL-D-GLUCURONO)-D-XYLAN ; GROWTH ; CANCER ; SEEDS ; MICE |
| 资助项目 | State Key Program of National Natural Science Foundation of China[31230022] ; Program of Shanghai Subject Chief Scientist[16XD1404500] ; Project of Shanghai Committee of Science and Technology[15495800300] ; National Natural Science Foundation of China (NSFC)[31670814] ; National Natural Science Foundation of China (NSFC)[21402224] ; Shanghai Science and Technology Development Funds[14YF1407800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000408286400062 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272474]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Qu, Huanhuan; Ding, Kan |
| 作者单位 | 1.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563000, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Univ Sci & Technol China, Nano Sci & Technol Inst, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shengzhou Inst Dendrobium Officinale, Shengzhou 312400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Han,Liu, Yanqiu,Qu, Huanhuan,et al. Structure analysis of a novel heteroxylan from the stem of Dendrobium officinale and anti-angiogenesis activities of its sulfated derivative[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,103:533-542. |
| APA | Yue, Han,Liu, Yanqiu,Qu, Huanhuan,&Ding, Kan.(2017).Structure analysis of a novel heteroxylan from the stem of Dendrobium officinale and anti-angiogenesis activities of its sulfated derivative.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,103,533-542. |
| MLA | Yue, Han,et al."Structure analysis of a novel heteroxylan from the stem of Dendrobium officinale and anti-angiogenesis activities of its sulfated derivative".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 103(2017):533-542. |
入库方式： OAI收割
来源：上海药物研究所
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