Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides
文献类型：期刊论文
| 作者 | Tian, Xiaobo1,2; Yu, Pengqiu1,2; Tang, Yubo1; Le, Zhiping2; Huang, Wei1,3 |
| 刊名 | SYNLETT
 |
| 出版日期 | 2017-09 |
| 卷号 | 28期号:15页码:1966-1970 |
| 关键词 | peptide side-chain ligation side-chain benzyl ester peptide hydrazide arginylglycylaspartic acid peptides branched cyclic peptides |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-0036-1588870 |
| 文献子类 | Article |
| 英文摘要 | Here, we report a peptide aspartic acid side-chain benzyl ester as a useful precursor that can be efficiently converted into various functional groups, including acid, amide, carbonyl hydrazide, carbonyl azide, or thio ester groups, without other protection for the peptide. With this strategy, we synthesized a series of novel branched and cyclic arginylglycylaspartic acid peptides through successive peptide C-terminal ligation and side-chain ligation based on a side-chain carbonyl azide or thio ester. |
| WOS关键词 | HYDRAZIDE LIGATION ; CHEMICAL-SYNTHESIS ; RGD ; ANTAGONISTS ; MIMETICS ; STRATEGY ; ASN |
| 资助项目 | National Natural Science Foundation of China (NNSFC)[21372238] ; National Natural Science Foundation of China (NNSFC)[21572244] ; Personalized Medicines: Molecular Signature-Based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020311] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000411346000019 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272500]  |
| 专题 | 生物技术药物研发中心（筹） 药物安全性评价中心 |
| 通讯作者 | Le, Zhiping; Huang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Receptor Res, Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Xiaobo,Yu, Pengqiu,Tang, Yubo,et al. Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides[J]. SYNLETT,2017,28(15):1966-1970. |
| APA | Tian, Xiaobo,Yu, Pengqiu,Tang, Yubo,Le, Zhiping,&Huang, Wei.(2017).Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides.SYNLETT,28(15),1966-1970. |
| MLA | Tian, Xiaobo,et al."Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides".SYNLETT 28.15(2017):1966-1970. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。