On-DNA Pd and Cu promoted C-N cross-coupling reactions
文献类型：期刊论文
| 作者 | Lu, Xiaojie1,2 ; Roberts, Sarah E.1; Franklin, George J.1; Davie, Christopher P.1
|
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 8期号:8页码:1614-1617 |
| ISSN号 | 2040-2503 |
| DOI | 10.1039/c7md00289k |
| 文献子类 | Article |
| 英文摘要 | Encoded library technology (ELT) is a novel hit identification platform synergistic with HTS, fragment hit ID and focused screening. It provides both an ultra high-throughput and a cost-efficient tool for the discovery of small molecules that bind to protein targets of pharmaceutical interest. The success of ELT relies heavily on the chemical diversity accessed through DNA-encoded library (DEL) synthesis. We developed unprecedented Pd and Cu(i) promoted C-N cross-coupling reactions between a DNA-conjugated aryl iodide and primary amines. These reported reactions have strong potential for application in DNA-encoded library (DEL) synthesis. |
| WOS关键词 | ENCODED CHEMICAL LIBRARIES ; SMALL-MOLECULE LIBRARIES ; ARYL HALIDES ; DISCOVERY ; TECHNOLOGY ; INHIBITORS ; RECEPTOR ; POTENT ; CHEMISTRY ; SELECTION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000407769400004 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272543]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Lu, Xiaojie |
| 作者单位 | 1.GlaxoSmithKline, New Chem Ent Mol Discovery, Platform Technol & Sci Drug Discovery & Select, 830 Winter St, Waltham, MA 02451 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Xiaojie,Roberts, Sarah E.,Franklin, George J.,et al. On-DNA Pd and Cu promoted C-N cross-coupling reactions[J]. MEDCHEMCOMM,2017,8(8):1614-1617. |
| APA | Lu, Xiaojie,Roberts, Sarah E.,Franklin, George J.,&Davie, Christopher P..(2017).On-DNA Pd and Cu promoted C-N cross-coupling reactions.MEDCHEMCOMM,8(8),1614-1617. |
| MLA | Lu, Xiaojie,et al."On-DNA Pd and Cu promoted C-N cross-coupling reactions".MEDCHEMCOMM 8.8(2017):1614-1617. |
入库方式： OAI收割
来源：上海药物研究所
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