Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines
文献类型：期刊论文
| 作者 | Zhai, Xian-Dong1; Yang, Zhong-Duo1; Luo, Zhi2; Xu, Hong-Tao2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2017-08 |
| 卷号 | 28期号:8页码:1793-1797 |
| 关键词 | Asymmetric catalysis Intramolecular aza-Michael reaction Primary amine Five and six-membered heterocycles Pyrrolidine and piperidine Enantioselective organocatalytic |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2017.04.017 |
| 文献子类 | Article |
| 英文摘要 | An intramolecular organocatalytic enantioselective aza-Michael reaction of carbamates, sulfonamides and acetamides to alpha,beta-unsaturated ketones was developed. This process is promoted by 9-amino-9deoxy-epi-quinine and diphenyl hydrogen phosphate to afford a straightforward and expeditious synthesis of several synthetically useful five- and six-membered heterocycles with excellent enantioselectivity (92%-97.5% ee) and very good yields (up to 99%). (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | CHIRAL PRIMARY AMINE ; ENANTIOSELECTIVE CONJUGATE ADDITION ; ALPHA,BETA-UNSATURATED KETONES ; CONCISE SYNTHESIS ; ALDOL REACTIONS ; ORGANOCATALYSIS ; PIPERIDINES ; ENONES ; NITROOLEFINS ; (+)-CONIINE |
| 资助项目 | National Natural Science Foundation of China[21262022] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6037505 |
| WOS记录号 | WOS:000407411600030 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272545]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang, Zhong-Duo |
| 作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhai, Xian-Dong,Yang, Zhong-Duo,Luo, Zhi,et al. Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines[J]. CHINESE CHEMICAL LETTERS,2017,28(8):1793-1797. |
| APA | Zhai, Xian-Dong,Yang, Zhong-Duo,Luo, Zhi,&Xu, Hong-Tao.(2017).Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines.CHINESE CHEMICAL LETTERS,28(8),1793-1797. |
| MLA | Zhai, Xian-Dong,et al."Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines".CHINESE CHEMICAL LETTERS 28.8(2017):1793-1797. |
入库方式： OAI收割
来源：上海药物研究所
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