Site-selective Csp(3)-H aryloxylation of natural product Tanshinone IIA and its analogues
文献类型：期刊论文
| 作者 | Liang, Bing3,4; Yu, Shujuan3,4; Li, Jie2,3; Wang, Fan3,4; Liang, Gaolin4; Zhang, Ao1,2,3 ; Ding, Chunyong1,3
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2017-05-10 |
| 卷号 | 58期号:19页码:1822-1825 |
| 关键词 | Natural product Tanshinone IIA Chemical modification Aryloxylation C-H activation |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2017.03.078 |
| 文献子类 | Article |
| 英文摘要 | A novel catalyst-free Csp(3)-H aryloxylation approach allowing for rapid installation of a wide range of aryloxyl groups regioselectively at the C-4 position of Tanshinone IIA under simple and mild conditions was developed. This unique protocol exhibited atom-/step-economy, low cost, high efficiency and robust functional-group tolerance, which will greatly facilitate to diversify the A-ring of the bioactive natural product. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SALVIA-MILTIORRHIZA BUNGE ; VASODILATIVE ACTIVITY ; OXIDATIVE STRESS ; DERIVATIVES ; ABSORPTION ; ACTIVATION ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[81402790] ; National Natural Science Foundation of China[81373277] ; National Natural Science Foundation of China[81430080] ; "Personalized Medicines Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020320] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000401204400004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272667]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Ding, Chunyong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.ShanghaiTech Univ, Shanghai 20120, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res Synthet Organ & Med Chem, Shanghai 201203, Peoples R China; 4.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liang, Bing,Yu, Shujuan,Li, Jie,et al. Site-selective Csp(3)-H aryloxylation of natural product Tanshinone IIA and its analogues[J]. TETRAHEDRON LETTERS,2017,58(19):1822-1825. |
| APA | Liang, Bing.,Yu, Shujuan.,Li, Jie.,Wang, Fan.,Liang, Gaolin.,...&Ding, Chunyong.(2017).Site-selective Csp(3)-H aryloxylation of natural product Tanshinone IIA and its analogues.TETRAHEDRON LETTERS,58(19),1822-1825. |
| MLA | Liang, Bing,et al."Site-selective Csp(3)-H aryloxylation of natural product Tanshinone IIA and its analogues".TETRAHEDRON LETTERS 58.19(2017):1822-1825. |
入库方式： OAI收割
来源：上海药物研究所
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