Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis
文献类型：期刊论文
| 作者 | Pu, Qinqin2,8; Gan, Changpei2,8; Li, Rongpeng1,8; Li, Yi2,8; Tan, Shirui8; Li, Xuefeng2,8; Wei, Yuquan2; Lan, Lefu7 ; Deng, Xin6; Liang, Haihua5
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| 刊名 | JOURNAL OF IMMUNOLOGY
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| 出版日期 | 2017-04-15 |
| 卷号 | 198期号:8页码:3205-3213 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.1601196 |
| 文献子类 | Article |
| 英文摘要 | Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure, with high morbidity and mortality. The literature implies that autophagy is a crucial regulator of inflammation in sepsis. In this article, we report that autophagy-related protein 7 (Atg7) is involved in inflammasome activation in Pseudomonas aeruginosa abdominal infection. Following i.p. challenge with P. aeruginosa, atg7(fl/fl) mice showed impaired pathogen clearance, decreased survival, and widespread dissemination of bacteria into the blood and lung tissue compared with wild-type mice. The septic atg7(fl/fl) mice also exhibited elevated neutrophil infiltration and severe lung injury. Loss of Atg7 resulted in increased production of IL-1 beta and pyroptosis, consistent with enhanced inflammasome activation. Furthermore, we demonstrated that P. aeruginosa flagellin is a chief trigger of inflammasome activation in the sepsis model. Collectively, our results provide insight into innate immunity and inflammasome activation in sepsis. |
| WOS关键词 | KLEBSIELLA-PNEUMONIAE INFECTION ; NOD-LIKE RECEPTORS ; HOST-DEFENSE ; AERUGINOSA INFECTION ; ALVEOLAR MACROPHAGES ; BACTERIAL-INFECTION ; IMMUNE-RESPONSE ; INNATE IMMUNITY ; UNITED-STATES ; CELL-DEATH |
| 资助项目 | Flight Attendant Medical Research Institute Grant[103007] ; National Institutes of Health Grants[AI101973-01] ; National Institutes of Health Grants[AI109317-01A1] ; National Institutes of Health Grants[AI097532-01A1] ; National Institutes of Health (NIH)/Institutional Development Award Networks of Biomedical Research Excellence Grant[P20GM103442] ; NIH/Centers of Biomedical Research Excellence Grants[P30GM103329] ; NIH/Centers of Biomedical Research Excellence Grants[P20GM113123] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000401127500021 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272698]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Liang, Haihua; Ma, Feng; Wu, Min |
| 作者单位 | 1.Jiangsu Normal Univ, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Jiangsu, Peoples R China; 2.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; 3.Peking Union Med Coll, Chengdu 610052, Sichuan, Peoples R China 4.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu 610052, Sichuan, Peoples R China; 5.Northwest Univ, Coll Life Sci, Key Lab Resources Biol & Biotechnol Western China, Minist Educ, Xian 710069, Shangxi, Peoples R China; 6.City Univ Hong Kong, Dept Biomed Sci, Kowloon Tong, Hong Kong, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Mat Med, Pudong Xinqu 201203, Shanghai Shi, Peoples R China; 8.Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA; |
| 推荐引用方式 GB/T 7714 | Pu, Qinqin,Gan, Changpei,Li, Rongpeng,et al. Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis[J]. JOURNAL OF IMMUNOLOGY,2017,198(8):3205-3213. |
| APA | Pu, Qinqin.,Gan, Changpei.,Li, Rongpeng.,Li, Yi.,Tan, Shirui.,...&Wu, Min.(2017).Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis.JOURNAL OF IMMUNOLOGY,198(8),3205-3213. |
| MLA | Pu, Qinqin,et al."Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis".JOURNAL OF IMMUNOLOGY 198.8(2017):3205-3213. |
入库方式： OAI收割
来源：上海药物研究所
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