中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis

文献类型:期刊论文

作者Pu, Qinqin2,8; Gan, Changpei2,8; Li, Rongpeng1,8; Li, Yi2,8; Tan, Shirui8; Li, Xuefeng2,8; Wei, Yuquan2; Lan, Lefu7; Deng, Xin6; Liang, Haihua5
刊名JOURNAL OF IMMUNOLOGY
出版日期2017-04-15
卷号198期号:8页码:3205-3213
ISSN号0022-1767
DOI10.4049/jimmunol.1601196
文献子类Article
英文摘要Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure, with high morbidity and mortality. The literature implies that autophagy is a crucial regulator of inflammation in sepsis. In this article, we report that autophagy-related protein 7 (Atg7) is involved in inflammasome activation in Pseudomonas aeruginosa abdominal infection. Following i.p. challenge with P. aeruginosa, atg7(fl/fl) mice showed impaired pathogen clearance, decreased survival, and widespread dissemination of bacteria into the blood and lung tissue compared with wild-type mice. The septic atg7(fl/fl) mice also exhibited elevated neutrophil infiltration and severe lung injury. Loss of Atg7 resulted in increased production of IL-1 beta and pyroptosis, consistent with enhanced inflammasome activation. Furthermore, we demonstrated that P. aeruginosa flagellin is a chief trigger of inflammasome activation in the sepsis model. Collectively, our results provide insight into innate immunity and inflammasome activation in sepsis.
WOS关键词KLEBSIELLA-PNEUMONIAE INFECTION ; NOD-LIKE RECEPTORS ; HOST-DEFENSE ; AERUGINOSA INFECTION ; ALVEOLAR MACROPHAGES ; BACTERIAL-INFECTION ; IMMUNE-RESPONSE ; INNATE IMMUNITY ; UNITED-STATES ; CELL-DEATH
资助项目Flight Attendant Medical Research Institute Grant[103007] ; National Institutes of Health Grants[AI101973-01] ; National Institutes of Health Grants[AI109317-01A1] ; National Institutes of Health Grants[AI097532-01A1] ; National Institutes of Health (NIH)/Institutional Development Award Networks of Biomedical Research Excellence Grant[P20GM103442] ; NIH/Centers of Biomedical Research Excellence Grants[P30GM103329] ; NIH/Centers of Biomedical Research Excellence Grants[P20GM113123]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000401127500021
出版者AMER ASSOC IMMUNOLOGISTS
源URL[http://119.78.100.183/handle/2S10ELR8/272698]  
专题药理学第三研究室
通讯作者Liang, Haihua; Ma, Feng; Wu, Min
作者单位1.Jiangsu Normal Univ, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Jiangsu, Peoples R China;
2.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China;
3.Peking Union Med Coll, Chengdu 610052, Sichuan, Peoples R China
4.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu 610052, Sichuan, Peoples R China;
5.Northwest Univ, Coll Life Sci, Key Lab Resources Biol & Biotechnol Western China, Minist Educ, Xian 710069, Shangxi, Peoples R China;
6.City Univ Hong Kong, Dept Biomed Sci, Kowloon Tong, Hong Kong, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Mat Med, Pudong Xinqu 201203, Shanghai Shi, Peoples R China;
8.Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA;
推荐引用方式
GB/T 7714
Pu, Qinqin,Gan, Changpei,Li, Rongpeng,et al. Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis[J]. JOURNAL OF IMMUNOLOGY,2017,198(8):3205-3213.
APA Pu, Qinqin.,Gan, Changpei.,Li, Rongpeng.,Li, Yi.,Tan, Shirui.,...&Wu, Min.(2017).Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis.JOURNAL OF IMMUNOLOGY,198(8),3205-3213.
MLA Pu, Qinqin,et al."Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis".JOURNAL OF IMMUNOLOGY 198.8(2017):3205-3213.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。