Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis
文献类型:期刊论文
作者 | Pu, Qinqin2,8; Gan, Changpei2,8; Li, Rongpeng1,8; Li, Yi2,8; Tan, Shirui8; Li, Xuefeng2,8; Wei, Yuquan2; Lan, Lefu7![]() |
刊名 | JOURNAL OF IMMUNOLOGY
![]() |
出版日期 | 2017-04-15 |
卷号 | 198期号:8页码:3205-3213 |
ISSN号 | 0022-1767 |
DOI | 10.4049/jimmunol.1601196 |
文献子类 | Article |
英文摘要 | Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure, with high morbidity and mortality. The literature implies that autophagy is a crucial regulator of inflammation in sepsis. In this article, we report that autophagy-related protein 7 (Atg7) is involved in inflammasome activation in Pseudomonas aeruginosa abdominal infection. Following i.p. challenge with P. aeruginosa, atg7(fl/fl) mice showed impaired pathogen clearance, decreased survival, and widespread dissemination of bacteria into the blood and lung tissue compared with wild-type mice. The septic atg7(fl/fl) mice also exhibited elevated neutrophil infiltration and severe lung injury. Loss of Atg7 resulted in increased production of IL-1 beta and pyroptosis, consistent with enhanced inflammasome activation. Furthermore, we demonstrated that P. aeruginosa flagellin is a chief trigger of inflammasome activation in the sepsis model. Collectively, our results provide insight into innate immunity and inflammasome activation in sepsis. |
WOS关键词 | KLEBSIELLA-PNEUMONIAE INFECTION ; NOD-LIKE RECEPTORS ; HOST-DEFENSE ; AERUGINOSA INFECTION ; ALVEOLAR MACROPHAGES ; BACTERIAL-INFECTION ; IMMUNE-RESPONSE ; INNATE IMMUNITY ; UNITED-STATES ; CELL-DEATH |
资助项目 | Flight Attendant Medical Research Institute Grant[103007] ; National Institutes of Health Grants[AI101973-01] ; National Institutes of Health Grants[AI109317-01A1] ; National Institutes of Health Grants[AI097532-01A1] ; National Institutes of Health (NIH)/Institutional Development Award Networks of Biomedical Research Excellence Grant[P20GM103442] ; NIH/Centers of Biomedical Research Excellence Grants[P30GM103329] ; NIH/Centers of Biomedical Research Excellence Grants[P20GM113123] |
WOS研究方向 | Immunology |
语种 | 英语 |
WOS记录号 | WOS:000401127500021 |
出版者 | AMER ASSOC IMMUNOLOGISTS |
源URL | [http://119.78.100.183/handle/2S10ELR8/272698] ![]() |
专题 | 药理学第三研究室 |
通讯作者 | Liang, Haihua; Ma, Feng; Wu, Min |
作者单位 | 1.Jiangsu Normal Univ, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Jiangsu, Peoples R China; 2.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; 3.Peking Union Med Coll, Chengdu 610052, Sichuan, Peoples R China 4.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu 610052, Sichuan, Peoples R China; 5.Northwest Univ, Coll Life Sci, Key Lab Resources Biol & Biotechnol Western China, Minist Educ, Xian 710069, Shangxi, Peoples R China; 6.City Univ Hong Kong, Dept Biomed Sci, Kowloon Tong, Hong Kong, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Mat Med, Pudong Xinqu 201203, Shanghai Shi, Peoples R China; 8.Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA; |
推荐引用方式 GB/T 7714 | Pu, Qinqin,Gan, Changpei,Li, Rongpeng,et al. Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis[J]. JOURNAL OF IMMUNOLOGY,2017,198(8):3205-3213. |
APA | Pu, Qinqin.,Gan, Changpei.,Li, Rongpeng.,Li, Yi.,Tan, Shirui.,...&Wu, Min.(2017).Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis.JOURNAL OF IMMUNOLOGY,198(8),3205-3213. |
MLA | Pu, Qinqin,et al."Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis".JOURNAL OF IMMUNOLOGY 198.8(2017):3205-3213. |
入库方式: OAI收割
来源:上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。