Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation
文献类型：期刊论文
| 作者 | Wu, Xiaowei1,3; Wang, Bao2,3; Zhou, Shengbin1,3; Zhou, Yu3 ; Liu, Hong3
|
| 刊名 | ACS CATALYSIS
 |
| 出版日期 | 2017-04 |
| 卷号 | 7期号:4页码:2494-2499 |
| 关键词 | ruthenium catalyzed cyclization one-carbon units [4+1] annulation isoindolinone |
| ISSN号 | 2155-5435 |
| DOI | 10.1021/acscatal.7b00031 |
| 文献子类 | Article |
| 英文摘要 | Internal alkynes have been used widely in transition-metal-catalyzed cycloaddition reactions, in which they generally serve as two-carbon reaction partners. Herein, we report ruthenium(II)-catalyzed redox-neutral [4 + 1] annulation of benzamides and propargyl alcohols, in which propargyl alcohols act as one-carbon units. This synthetic utility of propargyl alcohols led to a series of potentially bioactive N-substituted quaternary isoindolinones with moderate to high yields under mild conditions. Without the requirement for an external metal oxidant, this title transformation is compatible with various functional groups, which further underscores its synthetic utility and versatile applicability. In addition, preliminary mechanism experiments have been conducted and a plausible mechanism is proposed. |
| WOS关键词 | OXIDIZING DIRECTING GROUP ; N-N BOND ; INTERNAL ALKYNES ; O BOND ; ISOQUINOLONE SYNTHESIS ; OXIDATIVE ANNULATION ; CARBON STEREOCENTERS ; ASYMMETRIC-SYNTHESIS ; BICYCLIC ALKENES ; INDOLE SYNTHESIS |
| 资助项目 | National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000398986700030 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272724]  |
| 专题 | 药物化学研究室 药理学第一研究室 药物安全性评价中心 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Xiaowei,Wang, Bao,Zhou, Shengbin,et al. Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation[J]. ACS CATALYSIS,2017,7(4):2494-2499. |
| APA | Wu, Xiaowei,Wang, Bao,Zhou, Shengbin,Zhou, Yu,&Liu, Hong.(2017).Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation.ACS CATALYSIS,7(4),2494-2499. |
| MLA | Wu, Xiaowei,et al."Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation".ACS CATALYSIS 7.4(2017):2494-2499. |
入库方式： OAI收割
来源：上海药物研究所
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