Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds
文献类型：期刊论文
| 作者 | Wu, Yunxiang1,2; Zhou, Bing1,2
|
| 刊名 | ACS CATALYSIS
 |
| 出版日期 | 2017-03 |
| 卷号 | 7期号:3页码:2213-2217 |
| 关键词 | C-H activation ruthenium hydroxymethylation hydroxymethylarene formaldehyde |
| ISSN号 | 2155-5435 |
| DOI | 10.1021/acscatal.7b00078 |
| 文献子类 | Article |
| 英文摘要 | An ideal addition of "inert" aryl C-H bonds to formaldehyde has been achieved to synthesize a variety of hydroxymethylarenes via a Ru(II)-catalyzed C-H activation. Many different directing groups (not limited to strongly heterocyclic directing groups) can be used, and this challenging C-H hydroxymethylation proceeds in the presence of water and air, without stoichiometric undesirable byproducts, thus offering an environmentally benign method of hydroxymethylarene synthesis that can be readily scaled up. |
| WOS关键词 | OXIDATIVE ORTHO-ACYLATION ; O-METHYL OXIMES ; HETEROAROMATIC BASES ; CONVERGENT SYNTHESIS ; ORTHO-ALKENYLATION ; RHODIUM CATALYSIS ; CYCLATIVE CAPTURE ; ROOM-TEMPERATURE ; ACTIVATION ; ALDEHYDES |
| 资助项目 | CAS Pioneer Hundred Talents Program[00000000] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020333] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000395726500085 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272764]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhou, Bing |
| 作者单位 | 1.Chinese Acad Sci, SIMM, Dept Med Chem, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yunxiang,Zhou, Bing. Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds[J]. ACS CATALYSIS,2017,7(3):2213-2217. |
| APA | Wu, Yunxiang,&Zhou, Bing.(2017).Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds.ACS CATALYSIS,7(3),2213-2217. |
| MLA | Wu, Yunxiang,et al."Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds".ACS CATALYSIS 7.3(2017):2213-2217. |
入库方式： OAI收割
来源：上海药物研究所
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